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The complex nature of cancer involves not only uncontrolled proliferation but also the ability of malignant cells to survive under adverse conditions and to spread to distant sites. Chrysin, a natural flavonoid, is emerging as a compound with a remarkable capacity to interfere with these critical hallmarks of cancer, going beyond its well-established role in inducing apoptosis.
Research into Chrysin's anticancer effects has revealed its significant impact on cell survival pathways. Many cancer cells rely on aberrant signaling cascades, such as the PI3K/Akt pathway, for their sustained growth and resistance to therapy. Chrysin has been observed to inhibit these survival pathways, thereby promoting cell death and reducing the resilience of cancer cells.
One of the most devastating aspects of cancer is its ability to metastasize – the process by which cancer cells spread from the primary tumor to other parts of the body. This process is heavily dependent on cell migration and invasion, often facilitated by matrix metalloproteinases (MMPs) and epithelial-mesenchymal transition (EMT) processes. Studies have demonstrated that Chrysin can effectively inhibit cancer cell migration and invasion by downregulating key players like MMPs and EMT-related transcription factors.
For instance, in various cancer models, Chrysin has been shown to reduce the expression of MMP-10 and other MMPs, which are enzymes responsible for degrading the extracellular matrix, allowing cancer cells to invade surrounding tissues. By controlling these invasive properties, Chrysin directly interferes with the metastatic cascade.
The combined action of Chrysin – inducing apoptosis, inhibiting survival pathways, and suppressing metastasis – highlights its potential as a multi-target therapeutic agent. This comprehensive approach to tackling cancer offers a promising strategy for developing more effective treatments that not only kill cancer cells but also prevent the spread of the disease.
As research continues to unravel the intricate mechanisms by which Chrysin exerts its effects, its significance in both cancer prevention and treatment is becoming increasingly apparent. The exploration of Chrysin's role in modulating cell survival and metastasis is a critical step towards realizing its full therapeutic potential.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
