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The Critical Role of 4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile in Erlotinib Synthesis

In the intricate world of pharmaceutical synthesis, specific chemical intermediates serve as the bedrock for life-saving medications. One such vital compound is 4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile. This particular molecule plays a pivotal role in the creation of Erlotinib hydrochloride, a targeted therapy widely used in the treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer. Understanding its significance and ensuring a consistent, high-quality supply is paramount for pharmaceutical manufacturers and researchers.

4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile, identified by its CAS number 236750-65-5, is characterized by its molecular formula C₁₃H₁₆N₂O₆ and a molecular weight of 296.27600. Typically appearing as a white powder, its purity is often specified at 99%, a critical factor for its application in drug synthesis. The stringent requirements for pharmaceutical intermediates necessitate precise chemical profiles and reliable sourcing. For companies looking to purchase this essential raw material, identifying a reputable manufacturer and supplier is the first step towards ensuring the efficacy and safety of the final drug product.

The primary utility of 4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile lies in its function as a precursor in the multi-step synthesis of Erlotinib hydrochloride. Erlotinib itself is a potent epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, designed to interfere with tumor cell proliferation. The complex chemical structure of Erlotinib demands high-purity intermediates to achieve successful synthesis with minimal side reactions and by-products. Therefore, sourcing this intermediate from a reliable manufacturer in China, known for its robust chemical production capabilities, offers a strategic advantage in terms of both cost-effectiveness and supply chain stability.

For R&D scientists and procurement managers in the pharmaceutical sector, the selection of an appropriate supplier for 4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile involves a thorough evaluation of their manufacturing standards, quality control processes, and ability to provide consistent supply. When considering purchasing this compound, focusing on key search terms such as 'buy 4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile,' 'Erlotinib intermediate supplier,' or 'high purity 236750-65-5 price' will help identify leading manufacturers. We are committed to being that trusted source, offering not just the chemical itself, but also the assurance of quality and reliability that the pharmaceutical industry demands. Our manufacturing expertise ensures that we can meet the growing global demand for this critical intermediate, supporting the production of vital cancer therapies.

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NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

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3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).

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