Cyproheptadine Hydrochloride, identified by CAS 969-33-5 and also known as Cycloheptadine HCl, stands as a prominent first-generation antihistamine. Produced by NINGBO INNO PHARMCHEM CO.,LTD., this active pharmaceutical ingredient (API) is distinguished by its high purity, typically ranging from 98.0% to 101.0%. It presents as a fine white powder, making it suitable for various pharmaceutical formulations. With a molecular formula of C21H22ClN and a molecular weight of 323.859, Cyproheptadine Hydrochloride exhibits additional anticholinergic, antiserotonergic, and local anesthetic properties, setting it apart from many other antihistamines. Its multifaceted mechanism of action includes acting as a 5-HT2/5-HT1C serotonin receptor antagonist and an H1 histamine receptor antagonist, contributing to its diverse therapeutic applications.

The primary medical application of Cyproheptadine Hydrochloride is in the effective treatment of various allergic reactions. It is a go-to solution for conditions such as seasonal and perennial allergic rhinitis, commonly known as hay fever, providing significant relief from symptoms like runny nose, watery eyes, and itchy rashes. Furthermore, it is indicated for vasomotor rhinitis, allergic conjunctivitis triggered by inhalant allergens and certain foods, and mild, uncomplicated allergic skin manifestations including urticaria (hives) and angioedema. Its utility extends to ameliorating allergic reactions to blood or plasma transfusions, addressing cold urticaria, and managing dermatographism. In severe cases, it serves as an adjunctive therapy for anaphylactic reactions, complementing standard measures after acute manifestations are brought under control.

Beyond its conventional antihistaminic uses, Cyproheptadine Hydrochloride has found significant utility in several off-label applications. It is frequently employed as a preventive measure against migraine, particularly in children and adolescents, with studies suggesting a notable reduction in migraine frequency. Another notable off-label use is its role as an appetite stimulant, leading to weight gain. This property makes it valuable in treating children experiencing wasting and individuals with cystic fibrosis. It is also utilized in the management of moderate to severe serotonin syndrome, a potentially life-threatening condition associated with serotonergic drugs, and for high levels of serotonin resulting from carcinoid tumors. Additionally, its sedative effects make it a consideration for treating insomnia, and it is used off-label to improve akathisia in patients on antipsychotic medications, as well as for various dermatological conditions like psychogenic itch and drug-induced hyperhidrosis. In veterinary medicine, it acts as an appetite stimulant for cats and as an auxiliary treatment for feline asthma and equine pituitary pars intermedia dysfunction.

NINGBO INNO PHARMCHEM CO.,LTD. is a reliable manufacturer and supplier of high-quality Cyproheptadine Hydrochloride powder. Our product adheres strictly to international pharmaceutical standards, including USP and BP, ensuring consistent quality and efficacy for global distribution. We offer competitive prices for both bulk and smaller quantities, with flexible packaging options from 1kg bags to 25kg drums, tailored to meet specific client requirements. For those looking to buy or purchase this essential pharmaceutical ingredient, NINGBO INNO PHARMCHEM CO.,LTD. provides efficient and secure transit solutions, including Fedex, TNT, DHL, EMS, as well as air and sea freight for larger bulk orders. Our commitment to quality assurance and timely delivery makes us a preferred supplier for pharmaceutical companies worldwide. Please contact us to inquire about our product specifications, current price, or to discuss your purchase needs.