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The fight against cancer has been significantly bolstered by the introduction of targeted therapies, and cis-Diammineplatinum(II) Dichloride (Cisplatin) is a prime example of a highly effective chemotherapeutic agent. Its success stems from a precise and powerful mechanism of action that directly targets the DNA of cancer cells, leading to their demise. Understanding the cis-Diammineplatinum(II) dichloride anticancer mechanism is key to appreciating its therapeutic value.
Cisplatin, a platinum-based coordination complex, is a pro-drug that requires activation within the cellular environment. Once activated, it forms reactive platinum species that readily bind to nucleophilic sites on DNA, particularly the N7 position of guanine bases. The characteristic 'cis' geometry of the molecule allows it to form intra-strand cross-links, most commonly between adjacent guanines (GG adducts) and to a lesser extent between guanine and adenine (AG adducts).
These DNA adducts are not simply passive binders; they actively distort the DNA helix. This distortion leads to a cascade of cellular events. The cell's DNA repair machinery attempts to rectify these adducts, but the sheer number and specific type of cross-links formed by Cisplatin overwhelm these systems. The stalled replication forks and transcription machinery ultimately signal the cell to initiate apoptosis, or programmed cell death. This is the fundamental way Cisplatin functions as a platinum-based antineoplastic drug.
The efficacy of Cisplatin in treating various cancers, including ovarian, testicular, and lung cancers, is a testament to this targeted mechanism. However, cancer cells can develop resistance, often through enhanced DNA repair, altered drug metabolism, or increased drug efflux. Research into these resistance mechanisms is a critical part of pharmaceutical development of platinum compounds, seeking to overcome these challenges and improve treatment durability.
As a supplier of critical research chemicals, NINGBO INNO PHARMCHEM CO.,LTD. provides high-purity Cisplatin, enabling researchers to delve deeper into its molecular interactions and explore strategies to enhance its therapeutic potential. The study of the cis-Diammineplatinum(II) dichloride anticancer mechanism continues to inspire the development of novel cancer treatments and further solidifies Cisplatin's legacy in oncology.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
