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In the dynamic field of chemical synthesis and pharmaceutical research, understanding the properties and applications of key compounds is essential. (3R,4S)-Tofacitinib, identified by CAS number 1092578-46-5, is one such molecule that warrants attention from industry professionals. This article aims to demystify this compound, providing insights into its chemical nature, significance, and how it fits into the broader landscape of pharmaceutical development.
Chemical Identity and Properties
(3R,4S)-Tofacitinib is a specific stereoisomer with the molecular formula C16H20N6O and a molecular weight of 312.37 g/mol. Its precise structure, characterized by chiral centers at the piperidine ring, is critical for its intended applications. As a white powder, it is typically supplied with a purity exceeding 98%, making it suitable for high-stakes research and synthesis tasks. Its solubility in common organic solvents and its reactivity profile are key considerations for chemists when planning synthetic routes.
The Significance of Stereoisomers
In pharmaceutical chemistry, stereoisomers can exhibit vastly different biological activities and pharmacological profiles. (3R,4S)-Tofacitinib represents one specific spatial arrangement of atoms within a larger molecular framework. The ability to synthesize and isolate such specific stereoisomers is a testament to advanced chemical manufacturing capabilities. For researchers, having access to enantiomerically pure compounds like this is fundamental for developing targeted therapies and understanding complex biological pathways.
Applications in the Pharmaceutical Sector
The primary role of (3R,4S)-Tofacitinib is as a pharmaceutical intermediate. It is a crucial building block in the synthesis of certain active pharmaceutical ingredients (APIs), particularly those that involve JAK (Janus Kinase) inhibition pathways. Its precise stereochemistry is vital for ensuring the efficacy and safety of the final drug product. Professionals looking to buy (3R,4S)-Tofacitinib are typically involved in:
Sourcing and Supply Chain Considerations
The availability of (3R,4S)-Tofacitinib from reliable manufacturers is essential for uninterrupted research and development. When seeking a (3R,4S)-Tofacitinib supplier, professionals should prioritize those who can demonstrate consistent quality, competitive pricing, and a stable supply chain. Manufacturers in China are often a preferred choice due to their advanced production capabilities and cost-effectiveness. It is advisable to always verify the CAS number (1092578-46-5) and purity specifications when making a purchase.
Conclusion: A Vital Component for Innovation
(3R,4S)-Tofacitinib is more than just a chemical compound; it is an integral part of the innovation pipeline in the pharmaceutical industry. Its precise stereochemistry and role as a key intermediate make it indispensable for developing next-generation therapeutics. By understanding its properties and sourcing it from trusted suppliers, industry professionals can confidently advance their critical research and manufacturing endeavors.
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