Dexrazoxane Hydrochloride, identified by the CAS number 149003-01-0, is a significant active pharmaceutical ingredient (API) playing a critical role in modern oncology support therapy. As a high-purity chemical compound supplied in powder form, it is essential for formulators developing medications aimed at mitigating the adverse effects of certain potent chemotherapy regimens. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing Dexrazoxane Hydrochloride meeting stringent pharmaceutical standards, ensuring reliability for its global partners.

The primary application of Dexrazoxane Hydrochloride lies in its ability to prevent or reduce cardiac damage, specifically left ventricular dysfunction and congestive heart failure, caused by anthracycline chemotherapy agents such as doxorubicin and daunorubicin. These cytotoxic drugs are highly effective against a wide range of cancers, but their use is limited by cumulative dose-dependent cardiotoxicity, a serious and potentially life-threatening side effect. Dexrazoxane Hydrochloride acts as a catalytic inhibitor of topoisomerase II and, more importantly in this context, functions as an intracellular chelating agent. It is thought to form a complex that interferes with the iron-mediated free radical generation induced by anthracyclines, which is a major contributor to cardiac damage.

The availability of high-quality Dexrazoxane Hydrochloride API is therefore crucial for the formulation of cardioprotective drug products. These products allow oncologists to administer necessary doses of anthracycline chemotherapy while significantly lowering the risk of debilitating cardiac complications, thereby improving patient outcomes and quality of life during and after cancer treatment.

As a leading supplier of pharmaceutical raw materials, NINGBO INNO PHARMCHEM CO.,LTD. understands the critical importance of API purity, consistency, and compliance with regulatory requirements. The Dexrazoxane Hydrochloride supplied by NINGBO INNO PHARMCHEM CO.,LTD. typically presents as an almost white or white crystalline powder, a physical form ideal for downstream processing into various pharmaceutical dosage forms. Adherence to strict quality control protocols is paramount. Key specifications such as appearance, melting point, specific rotation, loss on drying, residue on ignition, heavy metals content, and relative substance impurities are meticulously tested to guarantee the API's suitability for pharmaceutical use.

Typical quality parameters for Dexrazoxane Hydrochloride include a high assay value, generally exceeding 99.0%. Testing for related substances is equally vital to ensure minimal impurities that could affect the safety or efficacy of the final drug product. Limits on single maximum impurities and total impurities are carefully monitored. Furthermore, control over physical characteristics like melting point and specific rotation confirms the identity and expected structural integrity of the compound. Parameters such as loss on drying and residue on ignition are controlled to ensure appropriate handling and stability characteristics of the powder.

Manufacturing of pharmaceutical APIs like Dexrazoxane Hydrochloride requires sophisticated synthesis processes and robust quality management systems. NINGBO INNO PHARMCHEM CO.,LTD. employs advanced production techniques and adheres to principles that align with international pharmaceutical manufacturing standards. Every batch undergoes rigorous analytical testing using validated methods such as High-Performance Liquid Chromatography (HPLC) for assay and impurity profiling, and Infrared (IR) spectroscopy for identification. This comprehensive testing regime ensures that the Dexrazoxane Hydrochloride consistently meets pharmacopoeial requirements and the high standards expected by pharmaceutical manufacturers worldwide.

The pharmaceutical industry relies on a dependable supply chain for critical APIs. Disruptions in the availability or quality of raw materials like Dexrazoxane Hydrochloride can have significant impacts on the production of essential medicines. NINGBO INNO PHARMCHEM CO.,LTD. is committed to maintaining a reliable production capacity and efficient logistics to support the continuous needs of its customers globally. The packaging of Dexrazoxane Hydrochloride, typically in protective cardboard drums or cartons, is designed to ensure the integrity and stability of the product during transport and storage.

Beyond standard supply, NINGBO INNO PHARMCHEM CO.,LTD. values collaboration and aims to be a responsive partner to pharmaceutical companies. Technical support and detailed product documentation are readily available to assist customers in their formulation and regulatory submission processes. Understanding the specific needs of drug developers and manufacturers is key to providing truly valuable service.

For pharmaceutical companies seeking a trusted manufacturer and supplier of high-quality Dexrazoxane Hydrochloride (CAS 149003-01-0), NINGBO INNO PHARMCHEM CO.,LTD. represents a source committed to excellence. Detailed information regarding product specifications, availability, and pricing can be obtained directly. We welcome inquiries from potential partners looking to buy or purchase this essential API. Understanding the current price and securing a reliable supply chain is crucial for pharmaceutical production planning, and NINGBO INNO PHCHEM CO.,LTD. is ready to facilitate this process. Reach out to discuss your requirements and learn more about the benefits of sourcing Dexrazoxane Hydrochloride from a dedicated and quality-focused partner.