The landscape of metabolic health and longevity research is constantly evolving, bringing promising compounds to the forefront. Among these, 5-Amino-1MQ, also known by its CAS number 42464-96-0, stands out as a subject of significant interest. This compound, supplied in a high-purity powder form, functions as a potent inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). Understanding the role of NNMT is crucial to appreciating the potential benefits offered by 5-Amino-1MQ.

NNMT is an enzyme that plays a role in the metabolism of nicotinamide, a form of Vitamin B3. It is particularly active in adipose (fat) tissue and the liver. By methylating nicotinamide, NNMT effectively reduces the pool of nicotinamide available for conversion into nicotinamide adenine dinucleotide (NAD+). NAD+ is a vital coenzyme found in all living cells, critical for fundamental biological processes, including metabolism, energy production, DNA repair, and cell signaling. Maintaining optimal NAD+ levels is increasingly recognized as important for overall cellular health and combating aspects of aging and metabolic dysfunction.

The primary mechanism through which 5-Amino-1MQ exerts its effects is by blocking the activity of NNMT. This inhibition leads to less nicotinamide being methylated and, consequently, more nicotinamide being available for the synthesis of NAD+. Elevated NAD+ levels have a cascade of positive effects within the cell. One particularly significant outcome is the activation of sirtuin-1 (SIRT1), often referred to as the "longevity gene." SIRT1 is a protein deacetylase that regulates numerous cellular pathways involved in stress resistance, metabolism, and aging.

Research, including studies conducted in animal models, has highlighted the potential of 5-Amino-1MQ in addressing metabolic challenges, particularly those associated with obesity. By inhibiting NNMT and boosting NAD+ levels, the compound can enhance cellular metabolic rate, encouraging cells, especially fat cells, to burn energy more efficiently. This mechanism can potentially lead to a reduction in fat accumulation (lipogenesis) and a decrease in the size of fat deposits. For instance, studies in mice demonstrated a notable reduction in body mass without alterations in food intake when supplemented with the compound, compared to control groups. This suggests a direct impact on metabolic efficiency rather than appetite suppression.

Beyond weight management, the activation of SIRT1 by elevated NAD+ levels holds promise for a wider array of health benefits. SIRT1 has been implicated in improving symptoms of obesity-related metabolic conditions, such as insulin resistance and dyslipidemia. Furthermore, its role in neuroprotection suggests potential cognitive benefits. The broad involvement of SIRT1 in cellular health underscores why increasing NAD+ through NNMT inhibition is considered a valuable strategy for supporting metabolic wellness and healthy aging.

As a leading provider of high-quality chemical raw materials, NINGBO INNO PHARMCHEM CO.,LTD. recognizes the growing interest in compounds like 5-Amino-1MQ (CAS 42464-96-0) for various research and application areas. We supply this product as a fine, high-purity powder, ensuring it meets stringent quality specifications, typically boasting a purity of 99% minimum as determined by HPLC. The physical appearance can range from yellow to orange or white powder, depending on the specific batch characteristics, but the quality and chemical integrity remain consistent. Proper storage in a cool, dry, dark location in a tightly sealed container is recommended to maintain stability and ensure a good shelf life.

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For those interested in exploring the potential of 5-Amino-1MQ powder for metabolic research, weight management applications, or related studies, obtaining a high-quality raw material is essential. NINGBO INNO PHARMCHEM CO.,LTD. offers competitive *price* options based on quantity and specific requirements. To *buy* or *purchase* this product, or to inquire about detailed specifications, lead times, and logistics, please contact our sales team. We are dedicated to supporting our customers with timely delivery and expert technical information. Choosing a reputable *supplier* like NINGBO INNO PHARMCHEM CO.,LTD. is crucial for ensuring the integrity and efficacy of your research and development projects involving 5-Amino-1MQ (CAS 42464-96-0) powder.