Custom Manufacturing, Project Outsourcing, your Trusted Partner from China
In the realm of advanced pharmaceutical formulations, particularly those involving nucleic acid delivery, the role of specialized lipids cannot be overstated. 1,2-Dioleoyloxy-3-(dimethylamino)propane, commonly known as DODAP, stands out as a critical ionizable cationic lipid. Its unique physicochemical properties make it indispensable for creating effective delivery systems such as lipid nanoparticles (LNPs) and liposomes. For procurement managers and R&D scientists looking to buy DODAP, understanding its synthesis, properties, and the benefits of sourcing from a reliable DODAP supplier in China is essential for successful project outcomes.
The Chemistry and Functionality of DODAP
DODAP is synthesized with two oleoyl (oleic acid) ester chains attached to a glycerol backbone, with a dimethylamino group at the sn-3 position. This structure imbues DODAP with amphipathic characteristics. The long, unsaturated oleoyl chains provide hydrophobicity, while the tertiary amine group offers a hydrophilic and, crucially, ionizable center. This ionizability means DODAP is neutral at physiological pH but becomes positively charged when protonated in acidic environments (typically pH below its pKa of around 8.02). This pH-dependent charge is the cornerstone of its utility in intracellular delivery.
When DODAP is incorporated into LNPs or liposomes, it plays a dual role:
Its relatively low cytotoxicity and ability to form stable particles further solidify its position as a preferred cationic lipid in many cutting-edge formulations, including those for mRNA vaccines and gene therapies.
Synthesis and Quality Considerations
The synthesis of high-purity DODAP involves esterification reactions and careful purification steps to remove impurities that could compromise its performance or safety. For pharmaceutical applications, achieving a purity exceeding 98% is often a prerequisite. When procuring DODAP, it's vital to work with a DODAP manufacturer that adheres to stringent quality control protocols and can provide comprehensive documentation, including Certificates of Analysis (CoA). Understanding the DODAP price in relation to its purity and the supplier's reliability is a key procurement strategy.
Why Partner with a Chinese Supplier?
As global supply chains evolve, many pharmaceutical companies are looking to China for high-quality chemical intermediates. NINGBO INNO PHARMCHEM CO.,LTD. is a premier DODAP supplier in China, offering:
We invite you to purchase DODAP from NINGBO INNO PHARMCHEM CO.,LTD. for your advanced formulation needs. Contact us today to discuss your requirements and receive a personalized quote.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
