Domperidone is a widely recognized pharmaceutical agent, classified as a dopamine antagonist, primarily valued for its antiemetic and prokinetic properties. It is extensively used to alleviate symptoms of nausea and vomiting, as well as to manage various gastrointestinal motility disorders. NINGBO INNO PHARMCHEM CO.,LTD. proudly offers high-quality Domperidone, meeting stringent pharmaceutical standards for diverse applications across the globe.

The therapeutic efficacy of Domperidone stems from its selective action as a peripheral antagonist of dopamine D2 and D3 receptors. Unlike some other dopamine antagonists, Domperidone has minimal ability to cross the blood-brain barrier. This selective action is crucial as it allows the drug to primarily target dopamine receptors located in the chemoreceptor trigger zone (CTZ)—a part of the brain that controls nausea and vomiting—and in the gastrointestinal tract. By blocking these peripheral receptors, Domperidone effectively enhances gastrointestinal peristalsis, promoting the movement of food through the stomach and intestines and reducing the sensation of sickness, while significantly mitigating central nervous system side effects often associated with other similar medications.

Domperidone's primary medical use is in the treatment of acute nausea and vomiting, whether caused by medication, such as those used in Parkinson's disease, or as a side effect of chemotherapy and radiotherapy. Its ability to accelerate gastric emptying makes it particularly effective in relieving discomfort associated with these conditions. It is also a recommended treatment for nausea linked to acute migraine episodes, offering much-needed relief for patients experiencing this debilitating symptom.

Beyond its antiemetic benefits, Domperidone serves a crucial role in managing specific gastrointestinal conditions. It is frequently prescribed for gastroparesis, a chronic condition characterized by delayed emptying of the stomach, often leading to nausea, vomiting, bloating, and early satiety. Domperidone helps to stimulate the transit of food, alleviating these distressing symptoms. Furthermore, it is effective in the symptomatic treatment of functional dyspepsia, a common disorder involving persistent upper abdominal pain or discomfort without an identifiable organic cause.

For optimal results, Domperidone is typically administered orally, approximately 15 to 30 minutes before meals. The usual adult dosage for treating nausea and vomiting ranges from 10 to 20 milligrams, taken three to four times daily, with a maximum daily dose not exceeding 80 milligrams. For functional dyspepsia, a dose of 10-20 milligrams three times daily may be prescribed. It is paramount that patients adhere strictly to their doctor's instructions, and treatment duration is generally limited to a short period, typically up to seven days, to minimize potential risks.

While generally well-tolerated, Domperidone can cause certain side effects. Common ones include dry mouth, headaches, anxiety, and mild abdominal cramps. More notably, due to its effect on dopamine receptors outside the blood-brain barrier, it can lead to elevated prolactin levels (hyperprolactinemia). This may manifest as breast enlargement, galactorrhea (unusual milk production), and menstrual irregularities in women, and gynecomastia or low libido in men. Of critical importance are the rare but serious cardiac side effects, including QT prolongation and ventricular arrhythmias, which carry a small increased risk of sudden cardiac death. This risk is higher with elevated doses, in older patients, or when taken concurrently with certain interacting medications. Therefore, Domperidone is contraindicated in individuals with pre-existing heart conditions, moderate to severe liver disease, or electrolyte imbalances. Patients must discontinue use and seek immediate medical attention if they experience symptoms like irregular heartbeat, fainting, or shortness of breath. It is essential to avoid co-administration with QT-prolonging drugs and strong CYP3A4 inhibitors.

As a leading manufacturer and supplier of pharmaceutical raw materials, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality Domperidone that meets global pharmaceutical standards. Our rigorous quality control processes ensure the purity and effectiveness of our active pharmaceutical ingredients (APIs). For companies and distributors seeking to purchase or buy premium Domperidone, NINGBO INNO PHARMCHEM CO.,LTD. offers competitive price options and reliable supply. We invite inquiries from partners looking for a trusted source for pharmaceutical-grade Domperidone, ensuring consistent quality and adherence to regulatory requirements for safe and effective medical applications.