20 YEARS OF PROFESSIONAL & DEDICATED SERVICE TO GLOBAL CUSTOMERS

Custom Manufacturing, Project Outsourcing, your Trusted Partner from China

Understanding the Impact of EDTA on Biochemical Assays: A Guide for Laboratories

At NINGBO INNO PHARMCHEM CO.,LTD., we understand the critical nature of accurate laboratory results. Ethylenediaminetetraacetic acid (EDTA) is a widely used anticoagulant in blood collection tubes, essential for preserving sample integrity for various tests. However, its potent chelating ability, while beneficial for anticoagulation, can also lead to interferences in specific biochemical assays. This is primarily because EDTA binds not only to calcium but also to other essential divalent metal ions that frequently act as cofactors for many enzymes.

These metal ions, such as magnesium, zinc, and iron, are vital for the optimal activity of numerous enzymes involved in metabolic pathways. When EDTA removes these ions from the solution, it can lead to a decrease in enzyme activity, potentially resulting in falsely low readings for analytes like liver enzymes (AST, ALT), renal function markers (BUN, UA), and even lipid profiles. For instance, enzymes that require magnesium as a cofactor might exhibit reduced activity in the presence of EDTA. This interference can complicate the interpretation of clinical chemistry results, underscoring the importance of careful sample selection and awareness of potential pre-analytical variables.

To mitigate these issues, laboratories often recommend using specific anticoagulant tubes based on the intended biochemical tests. While EDTA tubes are standard for hematology and some chemistry panels, tubes containing heparin (e.g., lithium heparin) are often preferred for assays where metal ion-dependent enzymes are being measured. Heparin has a weaker chelating effect and is less likely to interfere with enzyme cofactors. NINGBO INNO PHARMCHEM CO.,LTD. offers a range of high-quality anticoagulants, including both EDTA salts and heparin, to meet diverse laboratory needs. Choosing the correct anticoagulant tube, in consultation with laboratory guidelines, is a fundamental step in ensuring the accuracy and reliability of biochemical test results, thereby supporting effective patient care.

Manufacturing Facilities

NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

Professional Export Experience

to Global Customers

WHY CHOSE US?

1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;

2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;

3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).

FAQ

  • A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.

  • A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.

  • A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.

CONTACT US
Should you need to contact us; you may call during regular business hours, Monday through Friday, 8am – 6 pm.
NINGBO INNO PHARMCHEM CO.,LTD.
Address: No.163 Ruiqing Rd.,Ningbo 315000 China
Phone: 86-574-87319282
Fax: 86-574-27912196
SEND US AN EMAIL

NAME*

EMAIL*

COMPANY

COUNTRY*

MESSAGE*

Previous: The Role of Disodium EDTA in Food Preservation and Safety

Next: The Environmental Fate of EDTA: Challenges and Alternative Solutions

All Rights Reserved