For any professional involved in chemical procurement, especially within the pharmaceutical industry, understanding and verifying product specifications is non-negotiable. This guide focuses on 3-Ethynylimidazo[1,2-b]pyridazine (CAS: 943320-61-4), detailing the essential quality parameters that buyers should look for when sourcing this critical intermediate from manufacturers and suppliers.

The Importance of Precise Specifications for Pharmaceutical Intermediates

3-Ethynylimidazo[1,2-b]pyridazine is primarily utilized as an intermediate in the synthesis of Ponatinib, an important anti-cancer drug. In pharmaceutical synthesis, the purity and consistency of intermediates directly impact the quality, efficacy, and safety of the final Active Pharmaceutical Ingredient (API). Impurities, even in small amounts, can lead to side reactions, reduced yields, and potentially alter the pharmacological profile of the drug. Therefore, meticulous attention to specifications is paramount.

Key Specifications for 3-Ethynylimidazo[1,2-b]pyridazine: What Buyers Need to Know

When you are looking to buy 3-ethynylimidazo[1,2-b]pyridazine, ensure your supplier provides clear and verifiable information on the following:

• Chemical Name and Synonyms: The primary name is 3-Ethynylimidazo[1,2-b]pyridazine. Synonyms may include Ponatinib Impurity 1, among others.
• CAS Number: The unique identifier is 943320-61-4. This is crucial for accurate identification and regulatory compliance.
• Appearance: Typically described as a yellow powder. Visual inspection and consistency across batches are important.
• Assay/Purity: This is arguably the most critical specification. For pharmaceutical applications, a high purity is required, usually stated as ≥96.0% or preferably ≥98.0% by methods like High-Performance Liquid Chromatography (HPLC).
• Molecular Formula and Weight: C8H5N3 and approximately 143.15 g/mol are standard. These values are vital for stoichiometric calculations in synthesis.
• Storage Conditions: Recommended storage is often in a cool, ventilated place, or as specified (e.g., 2-8°C), which impacts shelf life and stability.

Sourcing from Reliable Manufacturers and Suppliers

When seeking a 3-ethynylimidazo[1,2-b]pyridazine supplier, particularly in regions like China known for chemical manufacturing, prioritize those who consistently provide comprehensive CoAs. These documents are the primary evidence of a product's quality and adherence to specifications.

To effectively purchase 3-ethynylimidazo[1,2-b]pyridazine, engage with suppliers who:

• Clearly list all relevant specifications.
• Provide Certificates of Analysis (CoA) with each order.
• Offer technical support or answer queries regarding product use.
• Have a good track record for quality and reliability.

The Impact of Quality on Your Project

Choosing a reputable Ponatinib intermediate manufacturer that adheres to stringent quality control ensures that your synthesis runs smoothly, your product yields are predictable, and the final API meets all regulatory and therapeutic standards. The pharmaceutical intermediate price should always be considered alongside quality and reliability to make an informed purchasing decision.

In conclusion, for any buyer of 3-Ethynylimidazo[1,2-b]pyridazine, a thorough understanding of its specifications and a commitment to sourcing from quality-assured manufacturers are fundamental to successful pharmaceutical R&D and production.