Ergothioneine, also known as EGT, is a naturally occurring amino acid derivative distinguished by its unique sulfur-containing structure. First discovered in the early 20th century, EGT is synthesized by certain bacteria and fungi, notably present in high concentrations in mushrooms. Unlike many other antioxidants, humans and animals cannot synthesize EGT endogenously, relying on dietary intake for its physiological benefits. This makes sourcing high-quality Ergothioneine crucial for leveraging its powerful properties in various applications, particularly in the health and beauty industries.

Chemically identified by the CAS number 497-30-3, Ergothioneine is a stable thiol-histidine betaine. Its stability is a key advantage, as the thiol group is protected within its unique ring structure, making it less susceptible to oxidation compared to other thiols like glutathione. This inherent stability ensures that EGT retains its potent antioxidant capacity under a wider range of conditions, making it an ideal ingredient for formulations where long-term efficacy and stability are paramount.

The biological significance of Ergothioneine is underscored by the existence of a specific transporter protein, OCTN-1, which facilitates its accumulation in various tissues and cellular compartments throughout the body. This targeted uptake allows EGT to reach areas particularly vulnerable to oxidative stress, such as the mitochondria and the nucleus. Mitochondria, the powerhouses of the cell, are constant generators of reactive oxygen species (ROS) and house mitochondrial DNA, which lacks the protective histones found in nuclear DNA, making it highly susceptible to damage. EGT’s ability to accumulate in mitochondria via OCTN-1 positions it as a frontline defender against mitochondrial oxidative damage, crucial for maintaining cellular health and function, particularly in high-metabolism tissues like the skin.

Beyond scavenging ROS like superoxides, Ergothioneine also neutralizes reactive nitrogen species (RNS), offering a broad spectrum of protection against different types of free radicals. Furthermore, studies indicate that EGT possesses the capacity to absorb ultraviolet (UV) radiation, adding another layer of defense against sun-induced skin damage, photoaging, and potential DNA mutations caused by UV exposure. Its presence helps to mitigate the cascade of events initiated by UV radiation, including inflammation and the degradation of extracellular matrix components like collagen and elastin.

The applications of Ergothioneine are diverse and rapidly expanding, driven by growing scientific evidence of its benefits. Its potent antioxidant and cytoprotective properties make it particularly valuable in the cosmetics and personal care industry. As a topical ingredient, Ergothioneine helps combat the signs of aging by reducing oxidative stress, which is a major contributor to wrinkles, fine lines, and loss of skin elasticity. Its ability to protect collagen and elastin fibers helps maintain skin firmness and resilience. It has also shown promise in reducing hyperpigmentation, commonly referred to as 'whitening spots,' and soothing skin inflammation, contributing to a more even-toned and calm complexion. The protective effects against sun damage make it an excellent addition to sunscreens and after-sun products, aiding in recovery and preventing long-term photo-induced damage.

Outside of cosmetics, Ergothioneine is gaining recognition in the food, dietary supplement, and health product sectors. As a dietary supplement, it offers systemic antioxidant support, protecting various organs and tissues from oxidative damage. Its potential neuroprotective effects, linked to its ability to cross the blood-brain barrier via OCTN-1 and protect neuronal cells from oxidative stress, suggest applications in cognitive health supplements. Research is also exploring its roles in cardiovascular health, immune function, and as a protective agent in certain medical contexts.

Compared to many other antioxidant ingredients, Ergothioneine stands out due to its unique transporter-mediated cellular uptake, remarkable stability, broad-spectrum free radical scavenging, and specific protection of vulnerable cellular components like mitochondrial DNA. These attributes make it a highly effective, safe, and mild ingredient suitable for sensitive skin and internal consumption.

Procuring high-quality Ergothioneine requires partnering with a reliable manufacturer and supplier. NINGBO INNO PHARMCHEM CO.,LTD. specializes in the production and supply of premium chemical raw materials, including Ergothioneine. We understand the critical need for purity, consistency, and transparency in the supply chain. Our Ergothioneine is available in different forms, primarily as a high-purity powder (typically 98% or 99%) and a 5% liquid solution, catering to various formulation needs in cosmetics, food, and supplements. The exact price of Ergothioneine varies depending on the purity, form, quantity ordered, and specific market conditions. We encourage interested parties to inquire directly to receive a detailed quotation based on their requirements.

For businesses looking to incorporate this powerful antioxidant into their product lines, knowing where and how to buy Ergothioneine is essential. Engaging with a trusted supplier like NINGBO INNO PHARMCHEM CO.,LTD. ensures access to material manufactured under stringent quality control standards, guaranteeing consistency batch to batch. We provide detailed specifications and analytical data for our product, giving our customers confidence in its quality and efficacy. Whether you are looking to purchase a small quantity for R&D or require bulk supply for large-scale production, our team is equipped to handle your needs and provide the necessary technical support. Investing in high-purity Ergothioneine is investing in the future of advanced health and beauty formulations.