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For chemists, formulators, and procurement managers in the pharmaceutical and fine chemical industries, understanding the precise specifications of a chemical compound is fundamental. Ethyl 3,4-bis(2-methoxyethoxy)benzoate, identified by its CAS number 183322-16-9, is a critical intermediate used in the synthesis of Erlotinib, a significant pharmaceutical agent. This article aims to provide a detailed overview of its chemical properties and offer guidance on selecting a reliable supplier for your sourcing needs.
Key Chemical Properties and Specifications
Ethyl 3,4-bis(2-methoxyethoxy)benzoate is characterized by its molecular formula C15H22O6 and a molecular weight of approximately 298.33 g/mol. Its EINECS number is 605-991-9. Physically, it is described as a white to almost white solid, with a melting point typically ranging between 55-58 °C. The boiling point is noted at approximately 401.7 ± 45.0 °C, and its density is around 1.102. For its primary application in pharmaceutical synthesis, particularly as an Erlotinib intermediate, high purity is essential. Reputable manufacturers often guarantee a purity level of ≥97%, with some offering ≥99% purity via Gas Chromatography (GC) analysis. These specifications are critical for ensuring the success of subsequent synthesis steps and the quality of the final API. When you decide to buy this chemical, always request a Certificate of Analysis (CoA) detailing these parameters.
The Importance of Purity and Application
The compound's role as an Erlotinib intermediate means that even minor impurities can have significant downstream effects. These could include reduced yields in synthesis, the formation of unwanted by-products, or even the presence of contaminants in the final drug substance. Therefore, sourcing from manufacturers who employ robust purification techniques and stringent quality control is paramount. The presence of the two methoxyethoxy groups and the ethyl ester on the benzoate core makes this molecule a specific and valuable precursor for constructing the complex structure of Erlotinib, a targeted therapy for certain cancers. If your R&D efforts or manufacturing processes require this specific intermediate, ensuring its quality is the first step to success.
Selecting a Reliable Manufacturer and Supplier
Choosing the right manufacturer and supplier for Ethyl 3,4-bis(2-methoxyethoxy)benzoate is a strategic decision. When looking to purchase this chemical, consider suppliers with a proven track record in producing pharmaceutical intermediates. Key indicators of reliability include:
Many leading chemical suppliers operate from China, offering competitive pricing and a wide range of products. By focusing on these criteria, procurement managers and R&D scientists can effectively identify and secure a dependable source for this crucial pharmaceutical intermediate, ensuring the continuity and quality of their critical drug manufacturing operations.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
