In the dynamic world of chemical synthesis, specialized building blocks are essential for creating molecules with targeted properties. Among these, fluorinated compounds hold significant importance due to the unique characteristics that fluorine imparts, such as increased lipophilicity, metabolic stability, and modified electronic properties. Ethyl 3-Amino-4,4,4-Trifluorocrotonate stands out as a key intermediate in this field.

Known also by synonyms such as (EZ)-Ethyl 3-amino-4,4,4-trifluorocrotonate, this compound has the molecular formula C6H8F3NO2 and a molecular weight of 183.128. Its physical appearance can range from a light yellow, transparent liquid to white crystals, depending on conditions, with a melting point around 26°C and a boiling point of 83°C at 15 mm Hg. These well-defined physical and chemical properties make it reliable for industrial and laboratory applications.

The significance of Ethyl 3-Amino-4,4,4-Trifluorocrotonate lies in its multifaceted reactivity, stemming from the presence of an amino group, an ester group, and a trifluoromethyl (CF3) group adjacent to a double bond. This structure makes it an invaluable synthon for constructing complex organic molecules, particularly those incorporating the highly desired trifluoromethyl moiety.

One of the primary application areas for Ethyl 3-Amino-4,4,4-Trifluorocrotonate is in pharmaceutical research and development. It serves as a precursor for synthesizing a wide range of biologically active compounds. The introduction of the trifluoromethyl group via this intermediate can significantly impact the pharmacokinetic and pharmacodynamic profiles of drug candidates, often enhancing efficacy and reducing side effects. It is particularly useful in creating fluorinated heterocycles and other complex scaffolds common in modern drug design.

Beyond pharmaceuticals, this versatile building block is also critical in the development of new pesticides and agrochemicals. The incorporation of fluorine, facilitated by intermediates like Ethyl 3-Amino-4,4,4-Trifluorocrotonate, can improve the stability and effectiveness of herbicides, insecticides, and fungicides. This contributes to the development of more targeted and environmentally favorable crop protection solutions.

Furthermore, Ethyl 3-Amino-4,4,4-Trifluorocrotonate finds applications in the field of new materials. Its unique structure allows for the synthesis of polymers and specialty chemicals with enhanced thermal stability, altered refractive indices, or other specific material properties required for advanced technologies.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality chemical raw materials and building blocks like Ethyl 3-Amino-4,4,4-Trifluorocrotonate. We offer this product to support innovation across the pharmaceutical, agrochemical, and materials science industries. As a reliable manufacturer and supplier, we understand the critical need for purity and consistency in these applications. Interested parties seeking to understand the current price, discuss supply chain options, or learn how to buy or purchase this essential fluorinated intermediate are encouraged to contact NINGBO INNO PHARMCHEM CO.,LTD. for detailed information and support.