In the complex landscape of pharmaceutical chemistry, specific intermediates serve as the backbone for creating life-saving medications. Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate, identified by CAS number 256504-39-9, is one such compound. Its importance is primarily tied to its function as a key intermediate in the synthesis of Riociguat, a crucial drug for treating pulmonary hypertension. For research scientists, formulators, and procurement managers, understanding the properties, applications, and supply chain of this chemical is vital.

Understanding the Compound's Properties and Role

Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate is an organic compound characterized by its molecular formula C13H14FN3O2 and a molecular weight of 263.27 g/mol. It typically appears as an off-white to yellow solid, with a high purity assay of at least 98.0%. This high purity is essential for pharmaceutical applications, ensuring that the final drug product meets stringent quality and safety standards. The compound's structure is ideal for its role as a precursor in the multi-step synthesis of Riociguat, a medication that stimulates soluble guanylate cyclase (sGC), improving blood flow in the lungs.

The consistent availability of high-quality Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate is a critical factor for pharmaceutical manufacturers involved in Riociguat production. Any variability in the intermediate can significantly impact the yield, purity, and overall cost-effectiveness of the final active pharmaceutical ingredient (API).

Key Considerations for Purchasing

When looking to purchase this essential pharmaceutical intermediate, several factors should guide your decision:

• Supplier Selection: Prioritize manufacturers and suppliers with a strong reputation in the fine chemicals and pharmaceutical intermediates sector. China is a significant source for these materials.
• Quality Verification: Always request and review the Certificate of Analysis (CoA) to confirm the product meets the required specifications, particularly the purity (≥98.0%).
• Quantity and Packaging: Determine your required quantity, from laboratory-scale research needs to commercial production volumes, and confirm the available packaging options (e.g., drums).
• Pricing and Quotation: Obtain quotes from multiple reputable suppliers to ensure competitive pricing. Factors like order volume, purity, and delivery terms will influence the final price.
• Logistics and Lead Times: Understand the supplier's delivery capabilities and lead times to align with your production schedules.

For research and development purposes, smaller quantities might suffice, while commercial manufacturing will require bulk purchases. Building relationships with reliable suppliers who can consistently deliver high-quality product is a strategic imperative.

Conclusion

Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate (CAS 256504-39-9) is more than just a chemical compound; it's a critical link in the chain of producing important therapeutic agents. By focusing on quality, supplier reliability, and obtaining competitive pricing, pharmaceutical companies can ensure a stable supply of this vital intermediate. If your company needs to buy this compound, engaging with experienced manufacturers and suppliers in China is a recommended approach to meet your production and research needs.