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Ethyl N-Cbz-4-Oxopyrrolidine-3-carboxylate: Chemical Properties and Handling for Researchers

Ethyl N-Cbz-4-Oxopyrrolidine-3-carboxylate, identified by CAS 51814-19-8, is a chemical compound frequently utilized in organic synthesis. For researchers and laboratory managers, a thorough understanding of its properties and appropriate handling procedures is essential for safe and effective laboratory work. This knowledge helps in selecting the right materials and ensuring the successful execution of synthetic protocols.

The physical appearance of Ethyl N-Cbz-4-Oxopyrrolidine-3-carboxylate is typically described as a white to off-white solid. Its molecular formula is C15H17NO5, with a molecular weight of approximately 291.3 g/mol. Key chemical properties reported include a density of around 1.273 g/cm³, a boiling point of 433.1°C at 760mmHg, and a flash point of 215.8°C. The pKa is predicted to be around 11.17±0.20. These parameters provide essential data for chemists when designing reaction conditions or calculating yields.

Regarding handling and storage, it is generally recommended that Ethyl N-Cbz-4-Oxopyrrolidine-3-carboxylate be stored in a cool, dry place, with the container kept tightly closed when not in use. This helps maintain its stability and prevents potential degradation from moisture or air. The compound is classified as an irritant, with hazard statements including H335 (may cause respiratory irritation), H315 (causes skin irritation), and H319 (causes serious eye irritation). Therefore, appropriate personal protective equipment (PPE) such as gloves, eye protection, and lab coats should always be worn when handling this chemical. Working in a well-ventilated area or under a fume hood is also advisable.

For B2B buyers looking to purchase this intermediate, it is vital to source from a reliable manufacturer or supplier. When you request a quote, inquire about the provided specifications, including purity (often 97%+) and any relevant safety data sheets (SDS). Understanding these details ensures you receive a product that meets your research needs and complies with laboratory safety standards. Consider requesting a free sample to verify quality before making a larger commitment.

By adhering to these guidelines for handling and storage, and by sourcing responsibly from trusted vendors, researchers can effectively utilize Ethyl N-Cbz-4-Oxopyrrolidine-3-carboxylate in their synthetic endeavors, contributing to advancements in chemical science and pharmaceutical development.

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