Ethyltriphenylphosphonium Iodide (ETPPI), with CAS number 4736-60-1, stands as a pivotal compound in modern organic chemistry. This phosphonium salt, characterized by its molecular formula C20H20IP and a molecular weight of 418.25 g/mol, typically appears as a white to off-white crystalline powder. Its melting point generally ranges between 164°C and 170°C, affirming its stable crystalline structure. ETPPI exhibits slight solubility in water but readily dissolves in common organic solvents such as acetone, chloroform, dichloromethane, and methanol, making it highly adaptable for various reaction environments. Due to its light-sensitive and hygroscopic nature, optimal storage involves an inert gas atmosphere, protected from light, and in a cool, dry place to maintain its high purity, typically ≥98% (Assay).

The versatility of Ethyltriphenylphosphonium Iodide is primarily showcased through its extensive applications across numerous scientific and industrial disciplines. Most notably, it is an indispensable reagent in the Wittig reaction, a fundamental process for the stereo-selective synthesis of alkenes from carbonyl compounds. This reaction is crucial in the production of a wide array of fine chemicals, including pharmaceuticals and agrochemicals, where precise control over molecular architecture is paramount. Beyond olefin formation, ETPPI also plays a significant role in cyclopropanation reactions, allowing for the creation of complex strained ring systems important in drug discovery and natural product synthesis.

Furthermore, ETPPI functions effectively as a phase-transfer catalyst. This capability allows it to facilitate chemical reactions between immiscible phases, thereby enhancing reaction rates and yields, particularly in heterogeneous systems. Its unique cationic phosphonium center contributes to its remarkable reactivity and ability to transfer ions between organic and aqueous layers. This catalytic property makes it a valuable tool for various synthetic transformations, including alkylation and acylation reactions, by promoting efficient interaction between reactants that would otherwise remain separated.

In the realm of advanced research, Ethyltriphenylphosphonium Iodide is explored for synthesizing bioactive molecules, contributing to the development of novel therapeutic agents. It is also a key component in material science, employed for modifying polymer structures to achieve desired properties, thereby expanding the utility of polymeric materials in high-tech applications. Its involvement extends to biological studies, where researchers investigate its influence on cellular processes by interacting with phospholipids, offering insights into cell signaling and membrane dynamics. In pharmaceutical development, ETPPI aids in the design and creation of compounds targeting specific biological pathways, thereby enhancing therapeutic efficacy and paving the way for new drug candidates.

For research institutions and chemical industries seeking a reliable manufacturer and supplier of high-quality Ethyltriphenylphosphonium Iodide, NINGBO INNO PHARMCHEM CO.,LTD. offers a consistent supply. Our commitment to stringent quality control ensures that every batch meets the highest purity standards required for demanding synthetic applications. We understand the critical importance of product integrity for your research and manufacturing needs. If you are looking to buy or purchase Ethyltriphenylphosphonium Iodide, we provide competitive price options and efficient logistics to global clients. Our robust production capacity ensures timely delivery for both small-scale laboratory needs and large-scale industrial requirements, making us a preferred partner in the chemical supply chain. We invite you to inquire about our product specifications and customized solutions to meet your specific demands for this essential chemical intermediate.