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The development of effective and stable tablets relies heavily on the selection of appropriate excipients. Among these, Povidone, commonly known as PVP, stands out for its exceptional binding capabilities, making it a preferred choice for pharmaceutical manufacturers. NINGBO INNO PHARMCHEM CO.,LTD. highlights the pivotal role of PVP as a binder in creating high-quality tablets.
PVP's primary function as a tablet binder is to provide the necessary mechanical strength to the compressed dosage form. This ensures that tablets do not fracture or crumble during handling and packaging. Whether employing wet granulation, dry granulation, or direct compression methods, PVP's adhesive properties facilitate the formation of robust granules and tablets. For example, PVP K30 binder for tablets is widely used due to its excellent adhesion and compatibility with various active pharmaceutical ingredients (APIs).
The effectiveness of PVP as a binder is attributed to its ability to form strong hydrogen bonds with drug particles, creating a cohesive matrix. This not only enhances tablet hardness but also influences other critical tablet properties such as disintegration and dissolution rates. A well-chosen binder like PVP ensures that the tablet breaks down appropriately in the gastrointestinal tract, releasing the API for absorption. This makes the use of polyvinylpyrrolidone pharmaceutical excipient crucial for predictable drug release profiles.
Manufacturers often utilize specific grades of PVP, such as PVP K17, for its particular binding characteristics. The concentration of PVP in tablet formulations typically ranges from 2% to 5%, with some applications utilizing as little as 0.5%. High molecular weight grades like PVP K90 offer strong adhesion with a lower dosage requirement, often around 1-3%. The consistent quality and performance of products available through suppliers like NINGBO INNO PHARMCHEM CO.,LTD. ensure manufacturers can rely on their chosen PVP grade for optimal results.
Moreover, PVP's versatility extends to its solubility. It is soluble in both water and various organic solvents, allowing for flexibility in granulation processes, especially for moisture-sensitive or heat-sensitive compounds. For instance, using an alcohol solution of PVP for granulation can mitigate stability issues and reduce drying times, thereby preserving the integrity of delicate APIs.
In essence, Povidone (PVP) is an indispensable excipient for tablet manufacturing. Its superior binding properties, coupled with its versatility in formulation and compatibility with various APIs, make it a key component in producing tablets that are both stable and therapeutically effective. NINGBO INNO PHARMCHEM CO.,LTD. offers reliable access to these essential pharmaceutical ingredients, supporting the production of high-quality medications.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
