In the intricate world of pharmaceutical synthesis, the quality and availability of key intermediates directly impact the success of drug development. 11α-Hydroxyprogesterone (CAS 80-75-1) stands out as a critical steroid intermediate, widely sought after by R&D scientists for its unique chemical structure and versatile applications. This article delves into the technical aspects and procurement considerations for this compound, aiming to equip researchers and procurement specialists with the knowledge to source it effectively.

Chemical Profile of 11α-Hydroxyprogesterone

11α-Hydroxyprogesterone, with the molecular formula C21H30O3 and a molecular weight of 330.46 g/mol, is characterized by its crystalline powder form, typically appearing white to light beige. Its CAS number, 80-75-1, is a universal identifier for this specific chemical entity. The presence of the alpha-hydroxyl group at the 11th carbon position differentiates it from other progesterone derivatives, influencing its reactivity and suitability for specific synthetic routes. For researchers, understanding its solubility, melting point (around 169°C), and stability is crucial for optimal laboratory practice. Ensuring a purity level of 99% is standard when sourcing for advanced pharmaceutical applications.

Applications in Pharmaceutical R&D

• Steroid Hormone Synthesis: This compound serves as a foundational intermediate in the synthesis of a range of steroid hormones and related pharmaceutical agents. Its structure allows for further functionalization, leading to complex therapeutic molecules.
• Endocrine Research: Its role as a natural hormone derivative makes it valuable in endocrinology research, aiding studies into hormonal pathways, receptor interactions, and metabolic processes. Scientists often purchase 11α-Hydroxyprogesterone for in-vitro and in-vivo biological assays.
• Precursor for APIs: As a key intermediate, it is a precursor for several Active Pharmaceutical Ingredients (APIs). Pharmaceutical companies rely on a steady supply of such intermediates to maintain their production pipelines.

Procurement Strategy for 11α-Hydroxyprogesterone

When seeking to purchase 11α-Hydroxyprogesterone, researchers and procurement managers should prioritize suppliers who can guarantee both quality and reliability.:

• Supplier Selection: Look for established manufacturers and suppliers with a strong reputation in the fine chemical and pharmaceutical intermediate market. Companies in China are often well-positioned as global suppliers due to their manufacturing capabilities and competitive pricing. Engaging with a direct manufacturer can often lead to better price points and more consistent quality.
• Technical Data and Support: A reputable supplier will provide comprehensive technical documentation, including detailed specifications, safety data sheets (SDS), and Certificates of Analysis (CoA) for each batch. Access to expert technical support can also be invaluable for troubleshooting and optimizing synthesis protocols.
• Order Management: Whether you need small quantities for initial research or bulk orders for pilot studies, ensure your chosen supplier can accommodate your volume requirements with predictable lead times. Competitive pricing is also a key factor; obtaining quotes from multiple trusted sources is advisable.

We are committed to supporting the pharmaceutical research community by providing high-purity 11α-Hydroxyprogesterone. We invite you to connect with us to learn more about our product specifications and to request a quote for your upcoming projects. Partnering with a reliable manufacturer ensures that your synthesis efforts proceed smoothly and efficiently.

Keywords: 11alpha-hydroxyprogesterone synthesis, pharmaceutical intermediate CAS 80-75-1, steroid chemistry, endocrine research chemicals, buy chemical intermediates, R&D supply, chemical manufacturer China.