In the highly specialized field of pharmaceutical synthesis, understanding the properties and applications of key chemical intermediates is vital for researchers and procurement professionals alike. 1-[3-(Benzyloxy)propyl]-5-formylindoline-7-carbonitrile, identified by its CAS number 1375180-30-5, is one such crucial compound, serving as a critical precursor in the manufacture of Silodosin, a leading medication for treating benign prostatic hyperplasia (BPH). This article offers expert insights into this intermediate, highlighting its chemical characteristics and strategic importance.

Chemical Properties and Significance of 1-[3-(Benzyloxy)propyl]-5-formylindoline-7-carbonitrile

Chemically defined as 5-Formyl-2,3-dihydro-1-[3-(phenylmethoxy)propyl]-1H-indole-7-carbonitrile, this compound possesses a molecular formula of C20H20N2O2 and a molecular weight of 320.385. It is typically supplied as a white powder, a characteristic that signifies high purity suitable for pharmaceutical applications. The precise molecular structure of this intermediate is engineered to facilitate the complex synthetic pathway leading to Silodosin. For R&D scientists, its well-defined properties, including a guaranteed assay of ≥98.0%, are essential for consistent experimental outcomes and for developing robust manufacturing processes. Its role is foundational in ensuring the final API meets all efficacy and safety standards.

Strategic Sourcing for Pharmaceutical Needs

For procurement managers, sourcing 1-[3-(Benzyloxy)propyl]-5-formylindoline-7-carbonitrile involves more than just finding a product; it requires identifying a reliable partner. When looking to buy this intermediate, prioritizing suppliers with established quality control systems and a proven track record is crucial. Many pharmaceutical companies source this compound from leading chemical manufacturers and suppliers in China, drawn by competitive pricing and efficient production capabilities. It is advisable to request detailed quotes and inquire about bulk purchasing options to optimize cost-effectiveness for commercial production.

Applications in Pharmaceutical R&D and Manufacturing

The primary application of 1-[3-(Benzyloxy)propyl]-5-formylindoline-7-carbonitrile is as a key intermediate in the synthesis of Silodosin. Silodosin's effectiveness in treating BPH symptoms, such as urinary hesitancy and frequency, makes it a significant therapeutic agent. The consistent availability of high-purity 1375180-30-5 supports the reliable production of this vital drug. Furthermore, R&D teams can utilize this compound for exploring new synthetic routes, improving existing processes, and conducting analytical studies to ensure the quality of the final pharmaceutical product. Researchers can confidently purchase this intermediate, knowing its specifications are tailored for demanding pharmaceutical applications.

Expert Advice for Buyers and Researchers

When engaging with potential suppliers for 1-[3-(Benzyloxy)propyl]-5-formylindoline-7-carbonitrile, experts recommend a thorough evaluation of their technical support and documentation. A strong relationship with a chemical supplier ensures not only product quality but also access to valuable technical information that can aid in process development. Companies that offer flexible packaging and delivery options can further streamline the procurement process. For those aiming to secure a reliable source, reaching out to established chemical providers for a quote is the first step towards building a productive partnership.

In summary, 1-[3-(Benzyloxy)propyl]-5-formylindoline-7-carbonitrile (CAS: 1375180-30-5) is an indispensable intermediate for Silodosin synthesis. By focusing on its chemical properties, quality specifications, and strategic sourcing from reputable suppliers, pharmaceutical professionals can ensure efficient and high-quality production. If you are looking to purchase this vital intermediate, secure a competitive price by contacting experienced chemical providers.