The field of organic synthesis constantly seeks novel building blocks that enable the creation of complex and functional molecules. N-[Tris(hydroxymethyl)methyl]acrylamide, identified by its CAS number 13880-05-2, stands out as a compound with significant potential for advanced chemical synthesis. As an R&D scientist or a synthetic chemist, understanding its properties and how to procure it reliably is crucial for your project’s success. This article offers expert insights into its applications and provides guidance on how to buy this versatile chemical.

The Molecular Advantage of N-[Tris(hydroxymethyl)methyl]acrylamide

The chemical structure of N-[Tris(hydroxymethyl)methyl]acrylamide is particularly interesting. It features an acrylamide group, which is highly reactive in polymerization and Michael addition reactions, coupled with a tris(hydroxymethyl)methyl moiety. This latter group, derived from Tris buffer (Tris(hydroxymethyl)aminomethane), provides multiple hydroxyl functional groups that can be further derivatized or used to impart specific properties, such as increased hydrophilicity or sites for cross-linking. These characteristics make it a sought-after intermediate for chemists aiming to synthesize specialized molecules.

Key Synthesis Applications

One of the primary applications for N-[Tris(hydroxymethyl)methyl]acrylamide is as a precursor in the synthesis of more complex acrylamide derivatives. As previously mentioned, its reaction with benzaldehyde yields N-(5-hydroxymethyl-2-phenyl-[1,3]dioxan-5-yl)-acrylamide. This type of reaction, forming acetals or related structures, is common in protecting group strategies or in building specific scaffolds for pharmaceutical intermediates or functional materials. Its high reactivity also makes it suitable for incorporation into polymers to modify their properties, such as improving water solubility or providing sites for post-polymerization modification.

Procuring High-Quality Material

When you decide to buy N-[Tris(hydroxymethyl)methyl]acrylamide, ensuring high purity is paramount. Researchers often require material with purity levels exceeding 98%, confirmed by analytical techniques like HPLC. Sourcing from reputable manufacturers is key to achieving this quality. Companies that specialize in fine chemicals and intermediates, such as NINGBO INNO PHARMCHEM CO.,LTD., are well-equipped to supply this compound. They typically provide detailed technical specifications and Certificates of Analysis (CoA).

Supplier Selection and Quotation Process

To identify the best N-[Tris(hydroxymethyl)methyl]acrylamide supplier, consider their experience in producing similar compounds, their quality control measures, and their responsiveness to inquiries. Requesting a quote is a vital step in the procurement process. When contacting a supplier, clearly state your needs: CAS number (13880-05-2), required purity, and the quantity you intend to purchase. This ensures that the quote provided is accurate and tailored to your specific project requirements, whether for R&D or pilot-scale synthesis.

By leveraging the unique chemical properties of N-[Tris(hydroxymethyl)methyl]acrylamide and engaging with reliable suppliers, synthetic chemists can unlock new avenues in molecular design and material innovation.