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The world of organic chemistry is rich with compounds that serve as critical building blocks for advanced materials and pharmaceuticals. Among these, 2-Chloro-N-(2,6-dimethylphenyl)acetamide stands out due to its pivotal role as a pharmaceutical intermediate. NINGBO INNO PHARMCHEM CO.,LTD. is at the forefront of supplying this compound, and understanding its chemical properties and synthesis is key to appreciating its value.
With the CAS number 1131-01-7, 2-Chloro-N-(2,6-dimethylphenyl)acetamide, also known by synonyms such as 2-chloro-2',6'-dimethylacetanilide, possesses a molecular formula of C10H12ClNO and a molecular weight of approximately 197.66 g/mol. Its physical appearance is typically described as beige needles or a crystalline powder. The compound exhibits a melting point in the range of 143-151°C, a characteristic that aids in its identification and quality assessment. Its solubility profile indicates it is generally insoluble in water but soluble in organic solvents like chloroform and methanol, which is typical for many organic intermediates used in synthesis.
The synthesis of 2-Chloro-N-(2,6-dimethylphenyl)acetamide commonly begins with 2,6-dimethylaniline. This precursor is reacted with chloroacetyl chloride, usually under controlled temperature conditions and in the presence of a base or catalyst. The reaction is a nucleophilic acyl substitution where the amine group of 2,6-dimethylaniline attacks the carbonyl carbon of chloroacetyl chloride, displacing chloride and forming the amide bond. Following the reaction, isolation and purification steps, such as crystallization, are employed to obtain the desired product with high purity. NINGBO INNO PHARMCHEM CO.,LTD. adheres to rigorous process controls to ensure that each batch of this chemical meets stringent purity requirements, crucial for its use in pharmaceutical applications. Exploring options to buy 2-Chloro-N-(2,6-dimethylphenyl)acetamide from a reliable supplier like us guarantees consistency.
The detailed characterization of this compound often involves techniques like NMR spectroscopy and IR spectroscopy to confirm its structure and purity. The N-H stretch and C=O stretch in IR spectroscopy, along with specific proton and carbon signals in NMR, provide definitive evidence of its molecular integrity. This level of analytical scrutiny is vital for a chemical intermediate destined for pharmaceutical use.
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