Polyethylene Glycol, commonly known as PEG, is a polyether compound with numerous applications, particularly in the pharmaceutical industry. These polymers vary widely in molecular weight, resulting in different physical states and properties. Among the most widely utilized grades for pharmaceutical applications are Polyethylene Glycol 4000 and Polyethylene Glycol 6000, often referred to as Macrogol 4000 and Macrogol 6000.

These specific grades are characterized by their higher molecular weights compared to their liquid counterparts, manifesting as a white powder or light white waxy solid at room temperature. They are highly valued for their unique combination of properties, making them indispensable excipients in various drug formulations. PEG 4000 and 6000 exhibit excellent solubility in water and many organic solvents, including alcohols, ketones, and aromatic hydrocarbons, while being insoluble in most aliphatic hydrocarbons and ethers. This solubility profile allows for flexibility in formulation design.

Furthermore, Polyethylene Glycol 4000 and 6000 demonstrate remarkable thermal stability and do not readily react with many chemicals, nor do they hydrolyze. These inert characteristics are critical for maintaining the stability and integrity of pharmaceutical products over time. Compliant with pharmacopoeial standards such as BP, USP, and EP, these grades ensure the necessary purity and quality required for medicinal use, identified by the CAS number 25322-68-3.

The applications of pharmaceutical grade PEG 4000 and 6000 are diverse and significant. They are frequently used as ointment bases, providing water-soluble matrices for topical drug delivery. Their ability to act as solvents for otherwise insoluble drugs makes them valuable in preparing injections and other liquid formulations. In the realm of drug delivery systems, PEG 4000 and 6000 serve as sustained-release carriers. By applying a PEG solution as a coating on pills, the diffusion of the drug can be controlled, thereby enhancing its efficacy and duration of action.

Beyond traditional drug formulations, these PEG grades are employed in more specialized applications. They are used for surface modification of medical polymer materials to improve biocompatibility, particularly in materials that come into contact with blood. In specific medical products, they contribute to the formulation of contact lens solutions, hydrophilic anticoagulant polyurethanes, and even alkanol contraceptive films. Their non-toxic and colloidal properties also make them suitable components in denture fixatives.

In the field of biotechnology, PEG 4000 and 6000 are widely used to promote cell fusion or protoplast fusion and assist organisms like yeast in DNA uptake during transformation processes. Their ability to absorb water in solution also makes them useful for concentrating solutions in laboratory settings.

The versatility, safety profile, and compliance with stringent quality standards make Polyethylene Glycol 4000 and 6000 essential raw materials for the pharmaceutical industry. For companies seeking to source these materials, it is important to connect with a reliable manufacturer or supplier. Understanding the current market price and available options to buy or purchase high-quality pharmaceutical grade PEG is crucial for ensuring the integrity and performance of finished drug products. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing quality pharmaceutical raw materials, including these vital PEG grades, supporting the development and production of effective and safe medicines.