Boc-GABA-OH, scientifically known as N-Boc-gamma-aminobutyric acid (CAS: 57294-38-9), is a valuable compound in organic chemistry, particularly recognized for its utility as a protected amino acid derivative and a key component in advanced synthetic strategies. Understanding its chemical properties is crucial for researchers and chemists looking to leverage its capabilities in various applications.

Physically, Boc-GABA-OH typically presents as a white powder. Its molecular formula is C9H17NO4, with a molecular weight of approximately 203.24 g/mol. This white crystalline powder form facilitates easy handling and accurate weighing in laboratory settings. The presence of the tert-butyloxycarbonyl (Boc) protecting group on the amine nitrogen of gamma-aminobutyric acid is its defining chemical feature. This carbamate-based protecting group is stable under a range of reaction conditions but can be selectively removed using moderately acidic reagents, such as trifluoroacetic acid (TFA) or hydrochloric acid in organic solvents. This selective deprotection is fundamental to its use in controlled synthesis.

The applications of Boc-GABA-OH are diverse and expanding. One of its most prominent roles is as a crucial linker in the synthesis of Proteolysis Targeting Chimeras (PROTACs). PROTACs are bifunctional molecules designed to induce the degradation of specific target proteins by recruiting them to the cell's ubiquitin-proteasome system. The Boc-GABA-OH moiety provides a flexible and reliable linkage point within these complex molecules, enabling precise spatial arrangement for effective target engagement and degradation. Researchers looking to buy Boc-GABA-OH for PROTAC development can depend on its consistent chemical structure and reactivity.

Furthermore, Boc-GABA-OH is widely employed in peptide synthesis. As a protected form of gamma-aminobutyric acid, it allows for its incorporation into peptide chains without interference from the amine group during coupling reactions. This is particularly useful when synthesizing peptides that require specific modifications or when incorporating non-canonical amino acids. Its availability as a high-purity chemical from reputable manufacturers and suppliers makes it an accessible tool for both academic research and industrial-scale peptide production.

Beyond these specific applications, Boc-GABA-OH serves as a versatile building block in general organic synthesis, offering a protected amino acid framework for creating a wide array of complex molecules. For procurement professionals and chemists in the pharmaceutical and chemical industries, understanding the sourcing options for this compound is key. Partnering with a reliable manufacturer and supplier, especially one based in China, can ensure access to high-quality Boc-GABA-OH at competitive prices. If you are seeking to buy this essential chemical, exploring the offerings of experienced suppliers is a critical first step.