N-Boc-D-phenylalaninol, identified by its CAS number 106454-69-7, is a compound of considerable interest within the realms of organic chemistry and pharmaceutical research. Its distinctive chemical structure and properties make it a valuable intermediate for a variety of synthetic processes. This article aims to explore the key chemical characteristics of N-Boc-D-phenylalaninol and its significant applications, particularly as a pharmaceutical intermediate.

The compound's chemical identity is precisely defined by its molecular formula C14H21NO3 and a molecular weight of 251.32. Physically, it typically presents as a white to light yellow crystalline powder. Its melting point ranges from 95-98°C, indicating a stable solid form under standard laboratory conditions. A crucial aspect of its utility is its purity, commonly specified as 95%min or higher, which is a critical factor for its use in sensitive synthetic procedures. The optical activity of N-Boc-D-phenylalaninol, with a specific rotation of +24°(23℃, c=1, CHCl3), highlights its chiral nature, making it indispensable for stereoselective synthesis.

The presence of the tert-butyloxycarbonyl (Boc) group is central to the compound's functionality. This protecting group renders the amine moiety inert to various reaction conditions, allowing chemists to perform transformations on other functional groups within the molecule or on reaction partners. Following the desired reactions, the Boc group can be readily removed under mild acidic conditions, regenerating the free amine. This selective protection and deprotection strategy is fundamental in N-Boc-D-phenylalaninol synthesis and its broader use in complex molecular construction.

As a pharmaceutical intermediate, N-Boc-D-phenylalaninol plays a vital role in the synthesis of numerous drug candidates and active pharmaceutical ingredients (APIs). Its structure, derived from D-phenylalanine, allows it to be incorporated into peptide-like structures or serve as a chiral scaffold for building more complex molecules. The compound is recognized for its role in the preparation of certain pharmaceuticals, including its use as a precursor for (S)-Amphetamine. The ability to reliably source high-purity intermediates like N-Boc-D-phenylalaninol is crucial for the pharmaceutical industry, supporting the consistent production of medicines.

Ningbo Inno Pharmchem Co., Ltd. is committed to providing researchers and manufacturers with high-quality chemical products, including this important intermediate. By offering reliable access to compounds with well-defined N-Boc-D-phenylalaninol CAS 106454-69-7 properties, they support the advancement of organic synthesis building blocks research. Companies seeking to purchase N-Boc-D-phenylalaninol can rely on such suppliers for materials that meet rigorous quality and purity specifications, essential for successful drug development and discovery.

In summary, N-Boc-D-phenylalaninol is a versatile and essential compound in modern chemistry. Its carefully controlled synthesis, distinct chemical properties, and critical role as a pharmaceutical intermediate solidify its importance in research and development, driving progress in the creation of new therapeutic agents.