Z-His-OH, identified by CAS number 14997-58-1, is a significant derivative of the amino acid L-histidine, widely recognized in the fields of chemistry and life sciences. Chemically designated as N-alpha-Carbobenzyloxy-L-histidine or Cbz-His-OH, this compound is a fundamental building block in complex organic synthesis, particularly in peptide chemistry. Understanding its chemical properties is key to leveraging its full potential in research and development.

The molecular structure of Z-His-OH combines the natural amino acid histidine with a carbobenzyloxy (Z) protecting group on its alpha-amino functionality. This protective moiety is crucial for preventing premature reactions at the amino group during synthesis, ensuring that peptide bonds are formed specifically at the carboxyl terminus. Histidine itself possesses an imidazole ring in its side chain, which is amphoteric and can act as both an acid and a base, making it important for protein structure, function, and catalytic activity. The presence of the Z group renders the alpha-amino group less reactive, allowing for selective reactions at the carboxyl group or the side chain under specific conditions.

The physical appearance of Z-His-OH is typically a white to off-white powder. Its solubility characteristics are important for synthetic chemists; it generally dissolves in organic solvents like chloroform, dichloromethane, ethyl acetate, and DMSO, which are commonly used in peptide synthesis. This solubility profile facilitates its incorporation into reaction mixtures and solid-phase synthesis resins.

The primary application of Z-His-OH is as a protected amino acid in peptide synthesis. Researchers and chemical manufacturers use it to introduce histidine into peptides for a variety of purposes. Histidine residues are known to be involved in metal binding, enzymatic catalysis, and maintaining protein structural integrity. Therefore, synthesized peptides containing histidine are of great interest in areas such as enzyme mimetics, metalloprotein research, and the development of novel therapeutics. If you are looking to buy Z-His-OH, seeking a product with consistent chemical properties from a reliable supplier is essential.

Beyond peptide synthesis, Z-His-OH can also serve as an intermediate in the synthesis of more complex organic molecules and heterocyclic compounds. Its unique imidazole side chain can be further functionalized, opening avenues for creating diverse chemical libraries for drug discovery. For those in need of this compound, searching for a reputable manufacturer that guarantees high purity and offers competitive prices is a wise procurement strategy. Whether you are a researcher investigating biochemical pathways or a chemist developing new synthetic routes, Z-His-OH offers significant utility.

In summary, Z-His-OH is a chemically versatile and indispensable compound in modern organic synthesis. Its well-defined properties and critical role in peptide chemistry make it a sought-after material. Partnering with a quality-focused Z-His-OH supplier ensures that your research and development efforts can proceed with confidence.