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Understanding the fundamental chemical properties of key intermediates is crucial for successful organic synthesis. NINGBO INNO PHARMCHEM CO.,LTD. highlights 3-Chloro-4-fluorobenzoic acid (CAS: 403-16-7), a compound whose distinct characteristics make it highly sought after in chemical research and industrial applications.
Physically, 3-Chloro-4-fluorobenzoic acid presents as a white solid, with a well-defined melting point range of 133-136°C. This indicates good thermal stability, a desirable trait for handling and processing in various chemical reactions. Its density is approximately 1.477, suggesting a relatively compact molecular structure. The compound's molecular formula, C7H4ClFO2, and molecular weight of 174.55700 further define its chemical identity.
Chemically, the presence of both chlorine and fluorine atoms on the benzoic acid ring significantly influences its reactivity. These electron-withdrawing halogens activate the molecule for various nucleophilic substitution and coupling reactions, making it an indispensable intermediate. The typical assay for this compound is ≥99.0% purity, ensuring high quality for precise synthetic transformations.
Regarding its synthesis, a common method involves the hydrolysis of 3-chloro-4-fluorobenzoyl chloride. This process typically entails reacting the benzoyl chloride derivative with a sodium hydroxide solution under controlled temperature conditions, followed by acidification with hydrochloric acid. The resulting product is then washed and dried to yield the desired 3-Chloro-4-fluorobenzoic acid in high yield. The efficiency of this synthesis pathway underscores why it remains a preferred method for commercial production.
For optimal preservation, it is recommended to store 3-Chloro-4-fluorobenzoic acid in a cool, ventilated place, ensuring its integrity and shelf life. Companies sourcing this material, whether for research purposes or large-scale manufacturing, benefit greatly from understanding these chemical properties and synthesis routes. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-purity 3-Chloro-4-fluorobenzoic acid, backed by our expertise in chemical synthesis and commitment to quality assurance, making us a reliable 3-Chloro-4-fluorobenzoic acid supplier in China.
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