1-Adamantanamine Hydrochloride, identified by its Chemical Abstracts Service (CAS) registry number 665-66-7, stands as a significant chemical intermediate with a diverse range of applications, particularly within the pharmaceutical industry. This compound, commonly presented as a fine white powder, is recognized for its unique chemical structure based on the adamantane cage.

The compound's chemical profile is well-defined. It possesses a molecular formula of C10H18ClN and a molecular weight of 187.71 g/mol. Key physical properties include a melting point typically reported as exceeding 300°C and a boiling point around 308.63°C. Its solubility in water is noted at approximately 50 mg/mL, indicating reasonable aqueous solubility essential for various formulations and processes. Proper storage involves maintaining the compound below +30°C to preserve its stability and integrity over time.

One of the most historically significant applications of 1-Adamantanamine Hydrochloride is its use as an antiviral agent. Specifically, it has been utilized in the prophylaxis and symptomatic treatment of Influenza A virus infections. Its mechanism of action against influenza A involves interfering with the function of the viral M2 protein ion channel, which is crucial for viral replication and assembly within the host cell. By blocking this channel, the compound inhibits the uncoating of the virus and prevents the release of viral ribonucleoproteins into the cytoplasm, thereby halting the replication cycle. While resistance has emerged in certain strains over time, its historical role and efficacy in susceptible strains remain noteworthy in the context of antiviral research.

Beyond its antiviral properties, 1-Adamantanamine Hydrochloride is perhaps even more widely recognized for its applications in treating neurological disorders, particularly as an antiparkinsonian agent. Its exact mechanism in Parkinson's disease is complex and multifactorial. It is known to act as a weak non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, a type of glutamate receptor found in the brain. By modulating NMDA receptor activity, it is thought to influence glutamatergic transmission, which plays a role in the motor symptoms of Parkinson's disease. Additionally, some studies suggest it may have effects on dopamine pathways, potentially by influencing dopamine release or reuptake, although this mechanism is less clearly defined than its NMDA antagonism.

The compound is not only used for primary Parkinson's disease but also finds utility in managing drug-induced extrapyramidal reactions, which are involuntary movement disorders that can be side effects of certain medications, especially antipsychotics. Its ability to modulate neurotransmitter activity helps in alleviating symptoms like tremor, rigidity, and bradykinesia associated with these conditions. Furthermore, it has been explored and used in the treatment of postherpetic neuralgia, a persistent nerve pain that can occur after a shingles infection, likely due to its NMDA receptor antagonist properties which can influence pain signaling pathways.

The quality and purity of 1-Adamantanamine Hydrochloride are of utmost importance, particularly when intended for pharmaceutical applications. A high level of purity, typically 99.5% minimum content, ensures the efficacy and safety of downstream products. Rigorous quality control measures, including analytical testing to confirm chemical identity, purity, and physical characteristics, are essential throughout the manufacturing process. Reputable manufacturers adhere to strict quality management systems to guarantee batch-to-batch consistency.

As a crucial raw material, the availability and reliable supply of 1-Adamantanamine Hydrochloride are vital for pharmaceutical production globally. Companies developing or manufacturing medications for influenza A, Parkinson's disease, or related neurological conditions require a consistent source of high-quality powder. The standard packaging often involves containers like 25kg drums or buckets, though customized packaging options can be provided to meet specific client needs. Efficient logistics and shipping are also key considerations when sourcing this material internationally.

NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated manufacturer and supplier of high-quality chemical intermediates, including 1-Adamantanamine Hydrochloride (CAS 665-66-7). We understand the critical need for purity, consistency, and reliability in the pharmaceutical supply chain. Our processes are designed to meet stringent quality standards, ensuring that the white powder we supply is suitable for demanding applications.

For businesses and research institutions looking to buy 1-Adamantanamine Hydrochloride or make a bulk purchase of CAS 665-66-7, partnering with an experienced and reliable source is crucial. We provide detailed product specifications and are available to discuss your specific requirements. Understanding the competitive price of 1-Adamantanamine Hydrochloride is an important aspect of procurement planning, and we strive to offer competitive terms for our high-quality product. As a leading 1-Adamantanamine Hydrochloride manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. is committed to supporting your production and research needs with a secure and consistent supply. Contact us to learn more about our product offerings and how we can serve as your trusted partner in chemical sourcing.