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Exploring the Versatility of 4-Amino-2, 6-Dichlorophenol in Synthesis

4-Amino-2, 6-Dichlorophenol, also recognized by its alternative name 3,5-Dichloro-4-Hydroxyaniline, stands as a pivotal chemical intermediate in numerous industrial processes. This compound, presenting typically as a white to light tan crystalline powder, is defined by its specific chemical structure featuring both an amino group and a hydroxyl group attached to a dichlorinated benzene ring. This unique arrangement is the source of its diverse reactivity and broad applicability across various chemical synthesis routes.

One of the primary sectors where 4-Amino-2, 6-Dichlorophenol demonstrates its indispensable value is pharmaceutical synthesis. Its reactive functional groups make it an excellent starting material for building complex molecular structures essential for active pharmaceutical ingredients (APIs). The ability to undergo various reactions, including coupling, substitution, and heterocycle formation, allows chemists to leverage this compound in creating novel therapeutic agents. Its purity and structural characteristics are often critical requirements for pharmaceutical-grade applications, ensuring that downstream products meet stringent quality and safety standards. It serves as a key precursor in the development of certain medicinal compounds, contributing specific structural motifs that can enhance drug efficacy or target specificity.

Beyond pharmaceuticals, 4-Amino-2, 6-Dichlorophenol is significantly utilized in the agrochemical industry. Here, it functions as an intermediate in the synthesis of various crop protection products, most notably herbicides. The introduction of chlorinated substituents into organic molecules is a common strategy in agrochemistry to enhance the persistence and activity of compounds against target pests or weeds. The phenol and amine functionalities provide sites for further modification, allowing for the creation of complex molecules tailored for specific agricultural needs. Its consistent quality is vital for producing effective and environmentally acceptable agrochemicals.

The dye manufacturing sector also benefits from the chemical properties of 4-Amino-2, 6-Dichlorophenol. It is employed in the synthesis of certain dyes, particularly azo dyes. Azo dyes are characterized by the azo group (-N=N-) linking two aromatic rings, and compounds like 4-Amino-2, 6-Dichlorophenol can serve as coupling components or diazo components in the reactions that form the azo link. Its inclusion can influence the resulting dye's color, solubility, and fastness properties, making it a valuable building block for creating vibrant and durable colors used in textiles, paper, and other materials.

Furthermore, 4-Amino-2, 6-Dichlorophenol finds applications in other specialized chemical fields, including coordination chemistry, where it can form complexes with metal ions, and material science, where it may be explored as a monomer or intermediate for synthesizing advanced functional materials. Its utility extends to cosmetic raw materials, hair care chemicals, detergent raw materials, and oral care chemicals, highlighting its broad utility based on its fundamental chemical reactivity and properties. These varied applications underscore its importance as a versatile building block in modern chemistry.

Understanding the chemical and physical properties of 4-Amino-2, 6-Dichlorophenol is essential for its effective use. It has a molecular formula of C6H5Cl2NO and a molecular weight of approximately 178.02 g/mol. While the precise appearance can vary slightly, it is typically a white to light tan crystalline powder. High purity is often specified, commonly at ≥97% as determined by techniques like High-Performance Liquid Chromatography (HPLC). Its melting point range is typically reported between 128 and 131°C, a characteristic property used for identification. The compound is reported to decompose before reaching a boiling point. Its density is approximately 1.58 g/cm³. Regarding solubility, it is known to be soluble in ethanol and slightly soluble in water, which guides its use in various reaction systems.

Proper storage and handling are crucial to maintain the quality and stability of 4-Amino-2, 6-Dichlorophenol. Recommended storage conditions involve keeping the material at a temperature range of 2-8°C, preferably in an amber container to protect it from light, and under an inert atmosphere to prevent oxidation. Storing it away from light and oxidizers is paramount to ensure its shelf life, which is typically around 24 months when stored correctly. Adherence to safety data sheet (SDS) guidelines is always recommended for safe handling in laboratory and industrial settings.

Ensuring the consistent quality of 4-Amino-2, 6-Dichlorophenol is a priority for reliable supply. Manufacturers employ rigorous quality control measures, including comprehensive testing of each production batch. A Certificate of Analysis (COA) is typically provided with shipments, detailing the product's specifications and the results of quality tests, such as purity, melting point, and appearance. Packaging is designed to protect the product during transit and storage, utilizing materials such as iron drums, plastic drums, IBC tanks, or bags, depending on the quantity and customer requirements. Reliable manufacturing processes support a consistent supply capacity to meet industry demands.

For industries and researchers requiring this critical intermediate, sourcing from a dependable partner is key. Those looking for a reputable manufacturer and experienced supplier of high-quality 4-Amino-2, 6-Dichlorophenol should evaluate potential partners based on their quality assurance protocols, production capabilities, and logistical expertise. Prospective buyers often seek detailed information regarding the current price, available quantities, and terms for bulk orders. Understanding the process to buy or purchase involves contacting suppliers for quotes, discussing specifications, and arranging delivery. A transparent supplier relationship ensures access to necessary documentation and technical support, facilitating the smooth integration of this product into various chemical synthesis and manufacturing processes globally.

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