This compound presents as an off-white to yellowish powder with a molecular formula of C6H4BrNO and a molecular weight of 186.00600. Key physical properties include a melting point typically around 93°C and a boiling point around 237.7°C at 760 mmHg. The density is approximately 1.683 g/cm³. Its solid powder form facilitates handling and storage compared to liquids, contributing to ease of use in manufacturing settings.

Analytical results consistently show high purity, typically exceeding 98.0%, with specific batches reaching levels like 99.83%. The melting point range is usually confirmed between 93-95°C, and moisture content is carefully controlled to be less than 0.5%. These rigorous standards ensure the material is suitable for demanding chemical processes.

The unique structure of 5-Bromo-2-pyridinecarbaldehyde, featuring both a bromine atom and an aldehyde group on the pyridine ring, makes it a versatile building block. It is extensively utilized in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients (APIs). Its reactivity allows for participation in various sophisticated chemical transformations.

For example, the aldehyde group can undergo reactions like reductive amination, condensation, and oxidation, serving as a handle for introducing diverse substituents or forming imine bonds. Simultaneously, the bromine atom acts as an ideal leaving group for metal-catalyzed cross-coupling reactions, enabling the formation of new carbon-carbon or carbon-heteroatom bonds. These reactions, including Suzuki, Stille, Sonogashira, and Buchwald-Hartwig aminations, are fundamental in constructing diverse heterocyclic structures and complex organic frameworks essential for medicinal chemistry and agrochemical development.

The strategic placement of the bromine and aldehyde groups on the pyridine ring opens pathways for creating complex molecules with specific biological activities. Its reliability and defined reactivity contribute significantly to the efficiency and yield of multi-step synthetic routes.

Beyond pharmaceuticals, 5-Bromo-2-pyridinecarbaldehyde finds application in the synthesis of other fine chemicals, including materials used in electronic applications or specialized polymers. Its broad utility underscores its importance as a chemical intermediate.

Ensuring the quality and consistency of 5-Bromo-2-pyridinecarbaldehyde is paramount for its intended applications. Strict manufacturing processes and analytical testing, including GC analysis for assay and melting point determination, are performed to guarantee that the material conforms to rigorous specifications, providing reliable performance in synthesis.

For researchers and manufacturers requiring high-quality 5-Bromo-2-pyridinecarbaldehyde, finding a reliable manufacturer and supplier is critical. Information regarding the current market price, availability, and specifications is readily available. Companies looking to buy or purchase this essential intermediate in bulk or smaller quantities can connect directly with trusted sources to ensure they receive material that meets their exact needs for purity and consistency.