NINGBO INNO PHARMCHEM CO.,LTD. is pleased to announce the availability of high-purity Mavacamten powder, a vital pharmaceutical raw material also recognized by its experimental designations SAR439152 and MYK-461. With the CAS number 1642288-47-8, Mavacamten represents a significant advancement in the therapeutic landscape for cardiovascular diseases, particularly hypertrophic cardiomyopathy.

Our commitment to quality is paramount. The Mavacamten powder supplied by NINGBO INNO PHARMCHEM CO.,LTD. boasts a high purity level, consistently meeting or exceeding 99%. This off-white powder has the molecular formula C15H19N3O2 and a molecular weight of 273.33, conforming to stringent quality control standards. We understand that for pharmaceutical applications, the integrity and consistency of the raw material are non-negotiable, which is why our manufacturing processes adhere to rigorous protocols to ensure every batch meets the required specifications.

Mavacamten's Mechanism of Action and Therapeutic Potential

Mavacamten is a first-in-class cardiac myosin inhibitor. Its primary application lies in the treatment of hypertrophic cardiomyopathy (HCM), a chronic, progressive disease characterized by excessive contraction of the heart muscle and impaired relaxation. This leads to reduced left ventricular filling and outflow obstruction, causing symptoms like shortness of breath, chest pain, and fatigue.

The mechanism by which Mavacamten exerts its therapeutic effect is highly targeted and novel. It functions as a small molecule modulator of cardiac myosin, specifically targeting the hypercontractility that is a hallmark of HCM. By binding to the cardiac myosin head, Mavacamten stabilizes the protein in an inhibited, energy-sparing state. This reduces the number of myosin heads available to interact with actin, thereby decreasing the excessive contractility of the sarcomere.

More precisely, Mavacamten has been shown to modulate multiple steps in the myosin chemomechanical cycle. It reduces the activity of the steady-state ATPase by inhibiting the rate of phosphate release from β-cardiac myosin-S1, which is often the rate-limiting step. Furthermore, it reduces the rate of myosin binding to ADP-actin and the rate of ADP release from myosin-S1. The cumulative effect of these actions is a reduction in the overall power output of the cardiac muscle, alleviating the hypercontraction and improving diastolic function, which is essential for proper heart filling and pumping efficiency in HCM patients.

The development of Mavacamten represents a paradigm shift in HCM treatment, moving beyond symptom management to directly address the underlying pathophysiology of excessive sarcomere contractility. As a leading supplier of pharmaceutical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. recognizes the importance of providing high-quality raw materials like Mavacamten to support the production of innovative therapies that can significantly improve patient outcomes.

Quality Assurance and Manufacturing Excellence

At NINGBO INNO PHARMCHEM CO.,LTD., quality assurance is integrated into every stage of production. From sourcing raw materials to the final packaging of Mavacamten powder, rigorous testing protocols are employed. Techniques such as High-Performance Liquid Chromatography (HPLC) are utilized to verify purity and ensure the absence of impurities. Our facilities operate under strict quality management systems to guarantee product consistency and reliability, meeting international standards relevant to pharmaceutical production.

We understand the importance of stability for pharmaceutical raw materials. Our Mavacamten powder is recommended for storage in a cool, dry, dark location within a tightly sealed container, ensuring a shelf life of 24 months when stored correctly. Standard packaging options are available to suit various needs, from smaller laboratory quantities to bulk orders, providing flexibility for research and large-scale manufacturing requirements.

Partnering with NINGBO INNO PHARMCHEM CO.,LTD.

For pharmaceutical companies and researchers seeking a reliable supply of high-purity Mavacamten powder (SAR439152, MYK-461), NINGBO INNO PHARMCHEM CO.,LTD. is your trusted partner. As a premier manufacturer and supplier of this critical active pharmaceutical ingredient (API) intermediate, we are equipped to meet global demand with efficiency and consistency. We offer competitive price options tailored to order volume and specific requirements. For those looking to buy Mavacamten powder, our dedicated sales team is available to provide detailed product information, technical support, and guidance through the purchase process. We facilitate seamless transactions and logistics to ensure timely delivery to your location. Our commitment is to support your development and manufacturing efforts by providing high-quality raw materials you can depend on. Whether you require sample quantities for evaluation or bulk supplies for commercial production, NINGBO INNO PHARMCHEM CO.,LTD. is ready to serve your needs for Mavacamten and other pharmaceutical intermediates. Contact us today to learn more about our Mavacamten powder and how we can assist your projects.