Feprazone, identified by CAS No. 30748-29-9, is a prominent non-steroidal anti-inflammatory drug (NSAID) widely recognized for its potent analgesic, anti-inflammatory, and antipyretic properties. With the molecular formula C20H20N2O2 and a molecular weight of 320.39, this compound represents a valuable asset in the pharmaceutical landscape, particularly for the management of various inflammatory and painful conditions.

Feprazone typically presents as a white or similar-to-white crystalline powder, devoid of odor but possessing a characteristic bitter taste. Its solubility profile is a key aspect of its chemical identity; it dissolves readily in chloroform, acetone, benzene, or a 10% sodium hydroxide solution, while exhibiting slight solubility in methanol or ethanol, and being insoluble in water. These properties are crucial for its formulation and therapeutic application. The compound boasts a melting point in the range of 152~157°C, with a density of 1.18 g/cm3, and a predicted pKa of 4.06.

At its core, Feprazone exerts its therapeutic effects primarily through the inhibition of cyclooxygenase (COX) enzymes, particularly showing a preferential inhibition of COX-2 over COX-1. This targeted action is instrumental in reducing the biosynthesis of prostaglandins, which are critical mediators of inflammation, pain signaling, and fever in the body. By attenuating prostaglandin production, Feprazone effectively mitigates the symptoms associated with inflammatory processes. Furthermore, research indicates Feprazone's role as an inducer of the P-450 2B family of cytochromes. Its antipyretic effect is achieved by modulating the hypothalamic heat-regulating centers, aiding in the dissipation of excess heat and lowering fever. Structurally similar to phenylbutazone, Feprazone offers a well-understood pharmacological profile.

Feprazone is extensively utilized for its broad spectrum of therapeutic applications. It is effectively employed in the treatment of active rheumatism, rheumatoid arthritis, and periarthritis, offering significant relief from pain and inflammation in these debilitating conditions. Beyond musculoskeletal disorders, Feprazone finds utility in addressing inflammation associated with upper respiratory tract infections, periodontium inflammation, and thrombophlebitis. Its versatility makes it a preferred choice for healthcare professionals seeking to manage chronic pain and inflammatory responses.

Ensuring the highest standards of purity and efficacy, Feprazone is manufactured to meet stringent specifications. Typically, the assay demonstrates a purity of not less than 99.0%, with very low levels of impurities such as loss on drying (not more than 1.0%), residue on ignition (not more than 0.1%), and heavy metals (not more than 10ppm). These rigorous quality controls guarantee a premium-grade product suitable for pharmaceutical applications. For optimal preservation, Feprazone should be stored in a cool and dry, well-closed container, away from moisture and strong light/heat, ensuring a shelf life of two years when stored properly. Consistent supply and prompt delivery are vital for pharmaceutical production. Reputable Feprazone manufacturers and Feprazone suppliers ensure that orders, often packaged in 25kg drums, are delivered efficiently, typically within two weeks of receiving prepayment. For those looking to buy Feprazone or purchase Feprazone, understanding the reliability of the Feprazone supplier and competitive Feprazone price points is essential to secure a consistent and high-quality source for this valuable active pharmaceutical ingredient.