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Fludarabine, identified by its CAS number 21679-14-1, is a potent antineoplastic agent that has significantly advanced the treatment of hematologic cancers. As a key pharmaceutical intermediate, its precise mechanism and applications are vital knowledge for researchers and clinicians alike. NINGBO INNO PHARMCHEM CO.,LTD. provides high-quality Fludarabine to support these critical efforts.
The primary mechanism of action for Fludarabine involves its role as a purine nucleoside analog. It works by inhibiting critical enzymes involved in DNA synthesis and repair, such as DNA polymerase alpha and ribonucleotide reductase. This disruption leads to an accumulation of DNA strand breaks and ultimately triggers apoptosis in cancer cells, particularly those with a high proliferation rate, characteristic of leukemias and lymphomas. Its effectiveness is especially noted in B-cell chronic lymphocytic leukemia (CLL), where it has been a standard treatment for many years.
The therapeutic applications of Fludarabine extend beyond CLL. It is also used in regimens for treating Acute Myeloid Leukemia (AML) and various types of Non-Hodgkin Lymphomas (NHL). Furthermore, its use in lymphodepletion before CAR T-cell therapy and in conditioning regimens for allogeneic hematopoietic stem cell transplantation (HSCT) highlights its multifaceted role in advanced cancer therapies. When sourcing this critical compound, ensuring the quality of the pharmaceutical raw material is paramount; purchasing Fludarabine powder from NINGBO INNO PHARMCHEM CO.,LTD. guarantees purity and consistency.
Understanding the appropriate fludarabine dosage is essential, as it is typically administered intravenously. The dose is carefully calculated based on the patient's body surface area and renal function to optimize efficacy while managing potential side effects. Common side effects can include myelosuppression, immunosuppression, gastrointestinal disturbances, and fatigue. Patients are closely monitored for these effects throughout their treatment course.
For institutions and companies seeking reliable sources for this crucial compound, NINGBO INNO PHARMCHEM CO.,LTD. offers Fludarabine of high purity, crucial for pharmaceutical development and research. Understanding the price of fludarabine and its availability is key for supply chain planning. We encourage inquiries for fludarabine bulkbuy options to ensure consistent supply for your needs.
In summary, Fludarabine (CAS 21679-14-1) remains a vital component in the fight against hematologic cancers. Its role in chemotherapy and advanced therapies underscores the importance of high-quality pharmaceutical intermediates. NINGBO INNO PHARMCHEM CO.,LTD. is committed to being a trusted supplier for this essential product.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
