Fluralaner, a highly effective systemic insecticide and acaricide, represents a significant advancement in veterinary parasitic control. As a key compound within the isoxazoline class, Fluralaner (CAS 864731-61-3) provides long-lasting protection against a wide range of external parasites, enhancing the health and well-being of animals globally. Its unique chemical structure allows for sustained efficacy, setting a new standard in veterinary medicine.

The primary mechanism of action for Fluralaner involves the selective inhibition of arthropod gamma-aminobutyric acid (GABA)-gated chloride channels and L-glutamate-gated chloride channels. These channels are crucial for the nervous system function of insects and mites. By binding to these specific receptors, Fluralaner causes uncontrolled neuronal activity, leading to paralysis and ultimately the death of the parasites. Crucially, its selectivity ensures a significantly lower binding affinity to vertebrate receptors, contributing to its favorable safety profile in mammals and birds, making it a reliable choice for animal treatment.

Fluralaner's applications are diverse, primarily targeting flea and tick infestations in companion animals. In dogs and cats, it is highly effective against common species such as the black-legged tick, American dog tick, brown dog tick, and lone star tick, as well as various flea species. The systemic nature of Fluralaner means that once administered, it is distributed throughout the animal's body, providing protection when parasites feed. This enables extended periods of efficacy, often offering up to 12 weeks (or 3 months) of continuous protection from a single dose, significantly simplifying treatment regimens for pet owners. Beyond companion animals, Fluralaner also plays a vital role in poultry health, effectively treating mite infestations, particularly red mites, when administered through drinking water solutions. It has also found off-label use in treating sarcoptic mange, demodectic mange, and ear mites in dogs and cats, and even skin and ear mites in rabbits and hedgehogs, showcasing its versatility.

While generally well-tolerated, like all medications, Fluralaner requires careful consideration. The most commonly reported side effects are typically mild and transient, including gastrointestinal disturbances such as vomiting, diarrhea, or decreased appetite. More rarely, neurological adverse reactions such as tremors, ataxia (loss of coordination), and seizures have been observed. Therefore, it is advised to use Fluralaner with caution in animals with a history of seizures or pre-existing neurological disorders. Safety in breeding, pregnant, or lactating animals, as well as very young or underweight animals, should always be assessed by a veterinary professional to ensure optimal outcomes. Following the recommended dosage and administration guidelines is paramount for ensuring the safety and effectiveness of the treatment.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying high-quality pharmaceutical ingredients like Fluralaner to meet the growing demands of the animal health industry. As a reputable manufacturer and supplier, we ensure stringent quality control and reliable delivery of active pharmaceutical ingredients (APIs). For inquiries regarding Fluralaner price, bulk orders, or to buy/purchase this essential veterinary compound, please do not hesitate to contact our sales team. We are committed to fostering healthier animal populations through advanced and effective solutions.