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For scientists and chemical professionals engaged in research and development, understanding the detailed technical specifications of a chemical compound is crucial for successful application. Fmoc-(S)-3-Amino-3-(4-bromophenyl)propionic acid (CAS 220497-68-7) is a high-value intermediate widely used in peptide synthesis and medicinal chemistry. This article provides a comprehensive overview of its key technical attributes and application areas.
At the heart of its utility is its structure: an amino acid derivative featuring the crucial Fmoc protecting group on the amino nitrogen and a 4-bromophenyl substituent on the beta-carbon. This specific configuration renders it a valuable building block for constructing peptides with modified side chains or for use in organic synthesis pathways where a brominated aromatic ring is required. Manufacturers often list its molecular formula as C24H20BrNO4 and its molecular weight as approximately 466.33 g/mol.
The purity of Fmoc-(S)-3-Amino-3-(4-bromophenyl)propionic acid is a critical parameter. Reputable suppliers, such as NINGBO INNO PHARMCHEM CO.,LTD., typically guarantee a purity of ≥97%, often confirmed by High-Performance Liquid Chromatography (HPLC). This high level of purity is essential to ensure efficient coupling reactions during peptide synthesis, minimize side products, and facilitate downstream purification processes. Other important specifications may include its appearance (typically an off-white to white solid or powder) and storage recommendations (often 2-8°C to maintain stability).
The primary applications for Fmoc-(S)-3-Amino-3-(4-bromophenyl)propionic acid lie in:
1. Peptide Synthesis: As a protected amino acid, it's used in solid-phase peptide synthesis (SPPS) to incorporate modified phenylalanine residues into peptide chains. This is vital for creating peptides with altered biological activity, stability, or targeting properties.
2. Drug Development: Its structure is beneficial in medicinal chemistry for the synthesis of novel small molecule drugs and peptidomimetics. The bromophenyl group can be a point for further functionalization or can influence the drug's interaction with biological targets.
3. Organic Synthesis: Beyond peptides, it serves as a chiral building block for various complex organic molecules, where precise stereochemistry and the presence of a bromophenyl moiety are advantageous.
When you need to buy this essential chemical, choosing a reliable manufacturer and supplier like NINGBO INNO PHARMCHEM CO.,LTD. ensures you receive material that meets these exacting technical standards. We are dedicated to providing the chemical research community with high-quality intermediates and intermediates.
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