For research and development scientists in the fields of chemistry and pharmaceuticals, a thorough understanding of chemical intermediates is crucial. Fmoc-Sta-OH (CAS 158257-40-0), also known as N-Fmoc-L-Statine, is one such compound that plays a significant role, particularly in peptide synthesis and drug discovery. This article aims to provide insights into its chemical characteristics and guide researchers on sourcing it effectively from reliable suppliers.

Key Chemical Properties of Fmoc-Sta-OH

Fmoc-Sta-OH is characterized by its molecular formula C23H27NO5 and a molecular weight of approximately 397.46 g/mol. Its physical appearance is typically a white powder. The critical functional group is the N-terminal Fmoc (9-fluorenylmethoxycarbonyl) protecting group, which is widely utilized in peptide synthesis due to its sensitivity to mild basic conditions. This allows for selective deprotection during the stepwise assembly of peptide chains without damaging the growing peptide molecule. Additionally, the presence of a hydroxyl group and a chiral center within its structure (specifically the 3S,4S configuration) makes it a valuable chiral building block for synthesizing complex and biologically active molecules.

The solubility profile of Fmoc-Sta-OH is important for its use in synthesis. It is generally soluble in common organic solvents used in peptide chemistry, such as dimethylformamide (DMF) and dichloromethane (DCM). Its melting point is typically in the range of 92-94°C, indicating a stable solid form under standard laboratory conditions. However, to maintain its long-term stability and purity, storage in a dry, cool place, often at -20°C, is recommended by most manufacturers. Understanding these properties is essential for researchers when planning experimental procedures and storage protocols.

What to Look for in an Fmoc-Sta-OH Supplier

When you need to buy Fmoc-Sta-OH for your R&D projects, selecting the right supplier is as important as understanding the chemical itself. Here are key attributes to consider:

1. Purity and Quality Assurance: Look for suppliers who guarantee high purity, ideally ≥98% (often verified by HPLC). Requesting a Certificate of Analysis (CoA) that confirms purity, identity, and other relevant parameters (like optical rotation) is standard practice.
2. Technical Support and Documentation: A good supplier will provide comprehensive product specifications, safety data sheets (SDS), and potentially offer technical support to answer your questions about handling and application.
3. Consistent Supply and Packaging: Ensure the manufacturer or supplier can provide the required quantities consistently and that the product is appropriately packaged to maintain its integrity during transit and storage. Companies offering various pack sizes, from grams to kilograms, cater to diverse R&D needs.
4. Competitive Pricing and Value: While quality is paramount, comparing Fmoc-Sta-OH price from different suppliers is also a practical consideration. However, always balance price against guaranteed quality and reliability. Bulk purchase discounts are often available.
5. Compliance and Traceability: For pharmaceutical R&D, traceability of materials and adherence to regulatory guidelines are important. Reputable manufacturers will have robust systems in place for lot traceability.

As a leading manufacturer of pharmaceutical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing researchers with high-quality Fmoc-Sta-OH. We understand that your research depends on the purity and reliability of the materials you use. By focusing on these aspects, we aim to be your trusted partner in advancing your scientific endeavors.