In the pursuit of enhanced cellular health and extended vitality, FOXO4-DRI peptide emerges as a significant innovation. This advanced senolytic compound is designed to specifically address the challenge of senescent cells, often referred to as "zombie cells," which accumulate with age and contribute to tissue dysfunction and various age-related diseases. NINGBO INNO PHARMCHEM CO.,LTD. is proud to be a leading supplier of high-purity FOXO4-DRI peptide, facilitating groundbreaking research and development in this critical area.

The core mechanism of FOXO4-DRI involves its unique ability to disrupt the interaction between the Forkhead box protein O4 (FOXO4) and the tumor suppressor protein p53. In senescent cells, FOXO4 forms a strong bond with p53, preventing p53 from initiating programmed cell death (apoptosis). This renders senescent cells resistant to the body's natural clearance mechanisms, allowing them to persist and secrete harmful pro-inflammatory factors, collectively known as the Senescence-Associated Secretory Phenotype (SASP), which can damage surrounding healthy tissue.

By mimicking a specific domain of the FOXO4 protein with D-amino acids, FOXO4-DRI acts as a competitive antagonist. It selectively binds to FOXO4, thereby freeing p53 to translocate to the cell's nucleus and mitochondria. This crucial relocation allows p53 to activate the apoptotic cascade, leading to the targeted removal of senescent cells without adversely affecting healthy, normally functioning cells. This selective elimination is paramount for restoring tissue homeostasis and improving overall cellular environment.

Research into FOXO4-DRI's applications has revealed a broad spectrum of potential benefits across various age-related conditions. Studies have indicated its promise in alleviating age-related testosterone secretion insufficiency by selectively targeting senescent Leydig cells, leading to improved endocrine function. Furthermore, FOXO4-DRI has shown potential in the field of cardiovascular health, with indications of its ability to improve cardiac function and vascular elasticity by clearing senescent cardiomyocytes and vascular smooth muscle cells. In neurodegenerative contexts, it is being explored for its capacity to reduce neuroinflammation and oxidative stress, potentially enhancing neurological function and delaying disease progression. A recent study highlights its compelling utility in addressing pathological scarring, specifically keloids, by inducing apoptosis in senescent fibroblasts and mitigating their pro-inflammatory and apoptosis-resistant microenvironment. It has also shown promise in enhancing the radiosensitivity of non-small cell lung cancer cells and reducing radiation-induced pulmonary fibrosis by targeting senescence-like fibroblasts.

As a dedicated manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. ensures the highest standards of quality and purity for FOXO4-DRI peptide. Our product is a white powder with a purity typically exceeding 99%, guaranteeing reliable results for sensitive research applications. For optimal stability and shelf life, it should be stored in a cool, dark, and tightly sealed container, maintaining its efficacy for at least two years. We understand the critical need for consistent quality in scientific endeavors, and our commitment to excellence underpins every batch produced.

For research institutions and pharmaceutical companies looking to buy FOXO4-DRI peptide for their studies, NINGBO INNO PHARMCHEM CO.,LTD. offers competitive pricing and flexible quantities to meet diverse research demands. Whether you require small quantities for initial investigations or are planning a larger purchase for extensive trials, our efficient supply chain ensures prompt delivery. We encourage interested parties to inquire about our bulk price options and discover how our high-quality FOXO4-DRI can advance their research into cellular longevity and regenerative medicine.