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Our genetic blueprint, DNA, is constantly subjected to damage from various sources, including environmental toxins, oxidative stress, and even normal metabolic processes. Maintaining genomic stability and ensuring efficient DNA repair are therefore fundamental for cellular integrity, preventing mutations, and staving off age-related diseases like cancer. At the core of these critical cellular defense mechanisms is Nicotinamide Adenine Dinucleotide (NAD+).
NAD+ is not just an energy-carrying coenzyme; it also serves as a crucial substrate for a family of enzymes known as Poly(ADP-ribose) polymerases (PARPs) and sirtuins. These 'genomic guardians' are directly involved in detecting and repairing DNA damage. PARPs, for instance, consume large quantities of NAD+ to add ADP-ribose units to proteins at sites of DNA breaks, signaling for repair machinery to be recruited. Sirtuins, on the other hand, utilize NAD+ to remove acetyl groups from histones and other proteins, which can modify chromatin structure and regulate gene expression, thus influencing DNA accessibility for repair.
The challenge arises because these DNA repair processes heavily consume NAD+. As NAD+ levels naturally decline with age, the efficiency of these critical repair pathways diminishes, leading to an accumulation of DNA damage and increased genomic instability. This accelerated damage can contribute to cellular senescence, organ dysfunction, and a higher risk of developing age-related pathologies. Therefore, strategies to maintain or boost NAD+ levels are pivotal for safeguarding cellular integrity and promoting healthy aging.
NINGBO INNO PHARMCHEM CO.,LTD. provides high-purity Nicotinamide Adenine Dinucleotide (NAD+) for researchers and manufacturers focused on this vital area. For those seeking a reliable supplier of NAD+ for genomic stability studies or a source of high purity NAD+ for DNA research, our product ensures the quality and consistency required for advanced investigations. Understanding and supporting NAD+'s role in DNA repair opens new avenues for combating age-related decline at its fundamental molecular level.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
