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HBTU, chemically known as O-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium Hexafluorophosphate (CAS.NO: 94790-37-1), stands as a cornerstone in modern organic synthesis, particularly in the demanding field of peptide chemistry. This off-white to white crystalline powder, with its distinct molecular formula C11H16F6N5OP and a molecular weight of 379.24200, is celebrated for its efficacy as a condensation and coupling reagent.
One of HBTU’s primary applications is in solid phase peptide synthesis (SPPS), where it facilitates the rapid and efficient formation of amide bonds between amino acid residues. Its mechanism involves activating carboxylic acids, ensuring high coupling yields while significantly minimizing racemization, a critical concern in peptide synthesis that can compromise the biological activity of the final product. The stability and high reactivity of HBTU make it suitable for both solid phase and in-solution synthesis, offering chemists a flexible and reliable tool.
Beyond peptide synthesis, HBTU’s versatility extends to other important transformations. It is adept at forming various amide and ester linkages, broadening its utility across diverse chemical landscapes. Notably, HBTU has been reported to efficiently and practically convert carboxylic acids into azides, a transformation valuable in click chemistry and other synthetic pathways. Furthermore, its application in the one-pot synthesis of dipeptidyl urea esters, ureas, and carbamates from carboxylic acids highlights its broad applicability and utility in creating complex molecules.
The physical and chemical properties of HBTU underscore its robustness: it boasts a melting point of 200°C (with decomposition) and a flash point of 200°C. For optimal preservation of its high purity (typically ≥99.0% by HPLC), HBTU should be stored in a cool, ventilated place, protected from light and moisture. NINGBO INNO PHARMCHEM CO.,LTD. ensures strict adherence to quality control, offering HBTU that consistently meets stringent specifications, making it a reliable choice for critical synthetic processes.
As a leading manufacturer and supplier of high-quality chemical reagents, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing superior HBTU. Our standard packaging includes 25 kg drums, with custom packaging options available to meet specific customer requirements. We understand the importance of reliable sourcing and competitive price for such essential reagents. Whether you are looking to buy HBTU for research, development, or large-scale production, NINGBO INNO PHARMCHEM CO.,LTD. offers a dependable pathway to purchase this vital product. Our commitment to excellence ensures that researchers and industrial partners have access to the finest HBTU, empowering innovation and efficiency in their chemical endeavors.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
