Hexafluoro-2-propanol (HFIP), also known by its chemical name 1,1,1,3,3,3-hexafluoropropan-2-ol and CAS No. 920-66-1, stands as a pivotal compound in modern chemistry. This colorless to pale yellow liquid, with a molecular formula of C3H2F6O and a molecular weight of 168.03800, is recognized globally for its extraordinary properties and broad utility across various scientific and industrial sectors.

Possessing distinct physical and chemical characteristics, HFIP has a low boiling point of 59°C and a melting point of -4°C. Its density is 1.596, and its refractive index ranges between 1.274 and 1.277. The most notable attribute of HFIP is its remarkable ability as a polar, strongly hydrogen bond-donating solvent. This unique feature enables it to effectively stabilize ionic species, efficiently transfer protons, and engage in a wide array of intermolecular interactions, setting it apart from many conventional solvents. The typical assay of ≥99.5% ensures its reliability and effectiveness in demanding applications where high purity is paramount.

While HFIP first appeared in chemical literature in a 1960 Swiss patent, it was initially considered more of a laboratory curiosity. However, over the past few decades, its true potential has been increasingly recognized. Comprehensive reviews have unequivocally highlighted HFIP as a highly versatile solvent, capable of facilitating an extensive range of chemical transformations and solving complex synthetic challenges.

The diverse applications of HFIP span multiple scientific disciplines:

• Organic Synthesis: In organic synthesis, HFIP excels as a powerful medium for numerous reactions. It is widely utilized in carbon-carbon bond formation, carbon-hydrogen functionalization, condensation, and cyclization reactions. Its significant role in promoting Friedel-Crafts reactions, facilitating the epoxidation of olefins with hydrogen peroxide, and even enabling metal-free C-H bond activation underscores its versatility. HFIP's ability to enhance selectivity and efficiency in complex reaction pathways makes it an indispensable tool for developing novel synthetic routes. It also plays a crucial role in various oxidation reactions and is instrumental in certain C-C cross-coupling and N-N bond formation processes.

• Electrochemical Methods: The compound has gained increasing traction in electrochemical processes, where its unique solvent properties enable more efficient electron transfer and product formation, opening doors for advanced electrochemical methodologies.

• Materials and Polymer Science: In the realm of materials and polymer science, HFIP is invaluable. It is employed in various polymerization techniques, including controlled radical polymerization, where it can influence molecular weight and tacticity. Its use extends to creating advanced materials like polymeric nanofiber scaffolds for biomedical applications and assisting in the orthogonal alignment of DNA, demonstrating its critical role in cutting-edge research and development.

  

• Biological Chemistry: Furthermore, HFIP has found applications in chemical biology, particularly in studies involving protein and peptide folding and the characterization of membrane mimics. Its influence on the secondary structure formation of peptides is a subject of ongoing research, offering deeper insights into complex biological phenomena.

NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated manufacturer and trusted supplier of high-quality 1,1,1,3,3,3-hexafluoropropan-2-ol. Available in standard 200 kg drums, packaging can also be customized to meet specific customer requirements. Proper storage in a cool, ventilated place ensures HFIP retains its exceptional purity and performance over time. For those looking to buy or purchase this essential chemical, competitive pricing and reliable supply are paramount, ensuring continuity for your research and production needs.

The unparalleled solvent properties and reactivity of Hexafluoro-2-propanol continue to make it a molecule of significant interest and an essential component for innovation across the chemical industry. Its role as an organic synthesis intermediate is continually expanding, solidifying its status as a cornerstone chemical for future advancements.