NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated supplier of high-quality pharmaceutical raw materials and intermediates. We are pleased to provide comprehensive details on one of our key offerings: 16-Beta Methyl Epoxide-8DM, commonly known as 8DM. Identified by CAS Registry Number 24916-90-3, this compound is a white crystalline powder characterized by its high purity, making it an essential building block in the synthesis of various pharmaceutical compounds.

Understanding the physical and chemical characteristics of 8DM is crucial for its effective application in synthesis. This substance presents as a white crystalline powder. Its molecular formula is C22H28O5, with a molecular weight of 372.46. The EINECS number associated with 8DM is 246-529-2. Rigorous quality control confirms a purity of minimum 99%, ensuring reliability for sensitive chemical processes. Key physical properties include a melting point typically within the range of 210-220ºC and a boiling point around 564.9±50.0ºC at standard atmospheric pressure (760 mmHg). The density is approximately 1.32, and it has a refractive index of 1.616. Its flash point is recorded at 198ºC. Solubility studies show it is readily soluble in DMSO, with a solubility of ≥150mg/mL (402.74 mM), which is important for solution-phase reactions. Proper storage is vital to maintain its integrity; it should be kept under controlled conditions, specifically at 2-8 degrees Celsius, offering a shelf life of approximately 3 years when stored correctly.

The primary application of 16-Beta Methyl Epoxide-8DM (8DM) lies in its function as a critical drug intermediate. It serves as a total material for the synthesis of various drugs, particularly playing a significant role in the production of adrenal hormones and acting as a steroid medicine intermediate. The pharmacological significance of compounds derived from 8DM is notable, especially concerning immunosuppressive effects. These effects are crucial in certain therapeutic areas and involve complex biological mechanisms. Research indicates that derivatives or compounds synthesized using 8DM can contribute to preventing or inhibiting cell-mediated immune responses, which are key components of the body's defense system and are involved in delayed allergic reactions.

Furthermore, the function associated with 8DM intermediates can involve reducing the number and activity of critical immune cells, including T lymphocytes, monocytes, and phagocytic cells. This reduction in cell numbers and their functional capacity contributes to the overall immunosuppressive profile. Another mechanism observed is the potential reduction in the ability of immunoglobulin to bind to cell surface receptors, thus modulating humoral immunity. Inhibition of interleukin synthesis and release is also a reported effect, which is significant because interleukins are crucial signaling molecules in the immune system. By reducing interleukin production and release, compounds derived from 8DM can decrease the transformation of T lymphocytes into lymphoblasts and subsequently reduce the spread of affectionary immune responses.

Additionally, intermediates like 8DM are understood to diminish immune replenishment through the basement membrane, impacting immune cell migration and access to tissue sites. They can also lead to a reduction in complement composition and immunoglobulin concentration, further influencing both innate and adaptive immune responses. These multifaceted immunosuppressive properties highlight the importance of 8DM as a starting material for synthesizing pharmaceuticals used in conditions requiring modulated immune activity, such as organ transplantation, autoimmune diseases, and certain inflammatory disorders.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality 16-Beta Methyl Epoxide-8DM (CAS 24916-90-3) that meets stringent pharmaceutical standards. Our production processes are designed to ensure high purity and lot-to-lot consistency. We provide a comprehensive Certificate of Analysis (COA) with every batch to confirm specifications. The product is typically supplied in secure packaging, such as per tin or drum, suitable for transport and storage. We offer flexibility in order quantities, with a typical minimum order quantity (MOQ) starting from 100g, catering to both research and production scale needs. Our logistics team ensures careful handling and adherence to recommended storage conditions during transport.

For pharmaceutical companies, research institutions, and manufacturers seeking a reliable source for this essential steroid medicine intermediate, NINGBO INNO PHARMCHEM CO.,LTD. stands ready to meet your requirements. As a reputable manufacturer and supplier of high-purity 8DM powder (CAS 24916-90-3), we understand the critical nature of your applications. We are transparent about our price structure and committed to offering competitive pricing for bulk orders and smaller quantities alike. If you are looking to buy 16-Beta Methyl Epoxide-8DM or wish to purchase this high-quality pharmaceutical raw material, please contact us to discuss your specific needs, obtain detailed specifications, and receive a quotation. Our team is available to provide technical support and assist you throughout the procurement process, ensuring a smooth and reliable supply chain for your synthesis requirements.