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High-Purity (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide HCl: A Vital Pharmaceutical Intermediate

In the dynamic landscape of pharmaceutical synthesis, certain chemical compounds stand out for their pivotal role in developing life-changing medications. Among these is (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide hydrochloride, a high-purity intermediate critical to the production of advanced therapeutic agents. Identified by its CAS Number 709031-39-0, this compound is meticulously synthesized to meet the stringent demands of the global pharmaceutical industry.


Chemically, (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide hydrochloride presents as an off-white to light brown solid, a physical characteristic indicative of its refined state. Its molecular formula, C6H11ClN2O, and molecular weight of 162.62 g/mol, underline its precise chemical composition. Extensive characterization confirms its stability and suitability for complex synthetic pathways. This compound exhibits a melting point above 192°C (with decomposition), and its solubility is slight in both DMSO and water, properties crucial for its application in various reaction environments.


The primary significance of (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide hydrochloride lies in its essential function as an intermediate in the synthesis of Saxagliptin (CAS: 361442-04-8) and Saxagliptin hydrochloride (CAS: 709031-78-7). Saxagliptin is a prominent dipeptidyl peptidase IV (DPP-IV) inhibitor, a class of drugs widely used in the management of type 2 diabetes. By inhibiting DPP-IV, Saxagliptin helps to improve glycemic control by enhancing the body's natural ability to lower blood glucose levels. The precise stereochemistry of this azabicyclo[3.1.0]hexane derivative is paramount, ensuring the correct three-dimensional structure required for the biological activity of the final pharmaceutical product. Its role as a foundational building block for such vital antidiabetes agents underscores its indispensable value in modern medicinal chemistry.


Quality and consistency are paramount when dealing with pharmaceutical intermediates. This product is manufactured under rigorous quality control standards to ensure exceptional purity, typically ≥99%. Furthermore, its water content is carefully controlled to ≤1.0%, and loss on drying is maintained at ≤0.5%. These strict specifications guarantee that the material is of the highest quality, minimizing impurities and maximizing efficiency in subsequent synthetic steps. Such high standards are vital for ensuring the efficacy, safety, and regulatory compliance of the active pharmaceutical ingredients derived from it.


For optimal preservation and to maintain its superior quality, (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide hydrochloride should be stored in a cool, dry, and well-closed container. It is imperative to keep the product away from moisture and strong light or heat, as these conditions can compromise its stability and purity over time. Standard packaging is available in 25kg cardboard drums, with flexible options for customer-specified requirements to accommodate diverse operational scales.


As a leading manufacturer and supplier of high-quality pharmaceutical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing researchers and drug developers with reliable and consistent access to (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide hydrochloride. We understand the critical demand for superior raw materials in the pharmaceutical industry and strive to offer competitive price options for bulk and specialized orders. For those looking to buy or purchase this essential intermediate, our comprehensive production capabilities ensure a steady and secure supply chain. Contact us today to learn more about our offerings and how we can support your advanced synthesis projects, ensuring you receive a product that meets the highest standards of quality and performance for your pharmaceutical needs.

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NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

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