2,6-Dichloropurine (CAS 5451-40-1): A Cornerstone in Modern Pharmaceutical Synthesis

In the dynamic realm of pharmaceutical development, the availability of high-quality intermediates is paramount. Among these, 2,6-Dichloropurine, identified by its Chemical Abstracts Service (CAS) number 5451-40-1, stands out as a critical building block. This versatile compound, with its unique chemical structure, serves as an essential precursor for a wide array of advanced medicinal compounds, driving innovation in drug discovery and manufacturing processes.

Chemically, 2,6-Dichloropurine is characterized by its molecular formula C5H2Cl2N4 and a molecular weight of 189.00. It typically presents as a white to light yellow crystalline powder, indicative of its high purity when properly synthesized. Key physical properties include a melting point ranging from 185 to 195 °C (with decomposition), a boiling point of approximately 405.4 °C at 760 mmHg, and a flash point of 231.3 °C. Its density is about 1.792 g/cm3, and it exhibits a refractive index of 1.741. This compound is renowned for its stability under normal temperature and pressure conditions, a crucial factor for its storage and handling in industrial settings. To maintain its integrity, it should be stored in a cool, dry place with the container kept tightly closed.

The significance of 2,6-Dichloropurine primarily lies in its extensive applications as a pharmaceutical intermediate. One of its notable uses is in the synthesis of 2,6-diamino-substituted purine derivatives, which are being explored as potential cardiomyogenesis inducing agents. This highlights its role in developing therapies for cardiac conditions. Furthermore, it is widely utilized in the preparation of various purine nucleosides and purine nucleotides, which are fundamental components of DNA and RNA, and are integral to numerous biological processes. These derivatives often serve as active pharmaceutical ingredients (APIs) or as crucial intermediates in the synthesis of antiviral agents, anticancer drugs, and other therapeutic compounds. Beyond its direct use in derivative synthesis, 2,6-Dichloropurine also plays a role in advanced chemical transformations, such as Suzuki-Miyaura cross-coupling reactions involving halopurines and arylboronic acids, demonstrating its versatility in complex organic synthesis pathways.

The industrial preparation of 2,6-Dichloropurine involves sophisticated synthetic routes designed to achieve high yields and purity. Common methods include the chlorination of xanthine (2,6-dihydroxypurine) using reagents like phosphorus oxychloride or phosphorus trichloride in the presence of specific catalysts or organic bases. Another approach involves the construction of the purine ring system from suitable starting materials such as barbituric acid derivatives or diaminopyridine compounds. Regardless of the specific synthetic pathway, stringent quality control measures are essential to ensure the final product meets the demanding specifications required for pharmaceutical applications. The consistent quality of 2,6-Dichloropurine directly impacts the efficacy and safety of the downstream pharmaceutical products.

For pharmaceutical companies and research institutions seeking this indispensable intermediate, finding a reliable manufacturer and supplier of 2,6-Dichloropurine (CAS 5451-40-1) is key. We are dedicated to providing high-quality chemical intermediates, ensuring excellent purity and consistent supply. When looking to buy 2,6-Dichloropurine, factors such as product assay, stability, and packaging options are paramount. Reputable suppliers offer various packaging sizes, from grams for research to kilograms for industrial production, ensuring flexibility for diverse needs. Comprehensive technical support and transparent price structures are also critical considerations for efficient purchase decisions. Engaging with an experienced supplier who adheres to strict quality standards guarantees the integrity of your production line and the success of your innovative pharmaceutical projects. We pride ourselves on being a trusted manufacturer of high-purity 2,6-Dichloropurine, ready to meet your supply demands with competitive pricing and unwavering commitment to excellence.

In conclusion, 2,6-Dichloropurine is more than just a chemical; it is a fundamental component driving progress in medicinal chemistry. Its pivotal role in synthesizing vital drug precursors underscores its value. As pharmaceutical research continues to evolve, the demand for high-grade 2,6-Dichloropurine will only intensify, cementing its status as an indispensable asset for innovative drug development globally.