3-Iodo-4-Methylbenzoic Acid (CAS 82998-57-0): A Cornerstone in Modern Chemical Synthesis

In the dynamic landscape of fine chemicals and pharmaceutical intermediates, 3-Iodo-4-Methylbenzoic Acid, identified by its CAS number 82998-57-0, emerges as a compound of exceptional significance. Also known by synonyms such as 4-Methyl-3-iodobenzoic acid or 3-Iodo-p-toluic acid, this chemical is an indispensable aromatic building block, revered for its multifaceted utility in complex organic syntheses. NINGBO INNO PHARMCHEM CO.,LTD. is proud to be a leading provider of this high-quality material, facilitating advancements across various industrial sectors.

Chemically, 3-Iodo-4-Methylbenzoic Acid boasts a molecular formula of C8H7IO2 and a molecular weight of 262.05 g/mol. It typically presents as an off-white to light yellow crystalline powder, signifying its high purity and crystalline structure. Key physical properties include a melting point generally ranging from 185-212°C, and good solubility in solvents like DMSO and methanol, while being slightly soluble in water. Our commitment to excellence ensures that the product supplied is of high purity, typically ≥98%, validated through rigorous analytical methods such as HPLC.

The strategic combination of a reactive iodine substituent, a carboxyl group, and a methyl substituent within its structure renders 3-Iodo-4-Methylbenzoic Acid incredibly versatile. The presence of the methyl group is particularly notable as it enhances lipophilicity, a critical factor for improving bioavailability in innovative drug design. This makes it an ideal compound for a broad spectrum of applications:

• Pharmaceutical Intermediates: It serves as a vital intermediate in the synthesis of various pharmaceutical compounds, including nonsteroidal anti-inflammatory drugs (NSAIDs), where precision and purity are paramount. Furthermore, it is instrumental in the preparation of specialized derivatives such as unlabeled N-succinimidyl 4-guanidinomethyl-3-iodobenzoate (SGIMB) and its Boc-protected analogue (Boc-SGMIB), compounds crucial for advanced research and development.
• Cross-coupling Reactions: Its reactive iodine atom makes it highly suitable for widely recognized cross-coupling reactions, including the Suzuki and Heck reactions. These powerful synthetic tools are fundamental in creating carbon-carbon bonds, enabling the construction of intricate molecular architectures found in pharmaceuticals, agrochemicals, and electronic materials.
• Metal-Organic Frameworks (MOFs): The compound's structural integrity and reactive sites make it valuable in the design and synthesis of MOFs, which are emerging as advanced materials for gas storage, separation, and catalysis.
• Liquid Crystal Synthesis: Its unique properties also contribute to the synthesis of liquid crystals, components critical for display technologies and other specialized optical applications.

At NINGBO INNO PHARMCHEM CO.,LTD., we understand the critical demand for reliable and high-quality chemical raw materials. Our state-of-the-art production facilities and stringent quality control protocols ensure that every batch of 3-Iodo-4-Methylbenzoic Acid meets the highest industry standards. We implement comprehensive testing, and a Certificate of Analysis (COA) accompanies each shipment, guaranteeing product integrity and consistency. We pride ourselves on maintaining an efficient global supply chain, ensuring fast and reliable delivery to our clients worldwide. Our expert team is dedicated to providing exceptional service, offering tailored packaging solutions and responding promptly to inquiries, fostering long-term, mutually beneficial partnerships.

For laboratories, research institutions, and manufacturing companies looking to buy or purchase high-purity 3-Iodo-4-Methylbenzoic Acid, NINGBO INNO PHARMCHEM CO.,LTD. stands as a premier manufacturer and supplier. We maintain robust production capabilities, allowing us to cater to orders of varying scales. We offer competitive price structures for bulk quantities, ensuring cost-effectiveness without compromising on quality. Contact us today to discuss your specific requirements, request a quotation, or learn more about how our superior quality 3-Iodo-4-Methylbenzoic Acid can support your innovative projects.