In the realm of cardiovascular medicine, angiotensin-converting enzyme (ACE) inhibitors represent a cornerstone in the management of conditions like hypertension and congestive heart failure. Among these vital compounds, Benazepril Hydrochloride stands out as a widely recognized and effective active pharmaceutical ingredient (API). Its role as a long-acting ACE inhibitor makes it invaluable in clinical practice, contributing significantly to patient health outcomes globally.

Benazepril Hydrochloride, often referred to by its CAS number 86541-75-5, is chemically defined by the molecular formula C24H28N2O5 and a molecular weight of 424.497. In its raw material form for pharmaceutical use, it typically presents as an off-White or White powder. The crucial aspect for its therapeutic efficacy and safety is its purity, with pharmaceutical grade material consistently achieving purity levels exceeding 99%, often verified through rigorous analytical methods like HPLC.

The mechanism of action for Benazepril Hydrochloride is centered on its inhibition of the angiotensin-converting enzyme. ACE is responsible for converting angiotensin I to angiotensin II, a potent vasoconstrictor and stimulator of aldosterone secretion. By blocking this enzyme, Benazepril Hydrochloride leads to reduced levels of angiotensin II, resulting in vasodilation and decreased aldosterone secretion. This cascade of effects culminates in lower blood pressure and reduced sodium and water retention, alleviating the symptoms and progression of hypertension and heart failure.

Upon oral administration, Benazepril itself acts as a prerequisite drug, being rapidly metabolized in the liver to its active form, benazeprilat. Benazeprilat is significantly more potent as an ACE inhibitor and is responsible for the therapeutic effects. The pharmacokinetic profile of Benazepril Hydrochloride, with its relatively long half-life, supports once-daily dosing, which improves patient compliance, a critical factor in managing chronic conditions like hypertension.

The primary clinical applications for pharmaceutical products derived from Benazepril Hydrochloride raw material include the treatment of essential hypertension and the management of congestive heart failure. For hypertensive patients, it helps to lower elevated blood pressure, reducing the risk of associated cardiovascular events such as stroke and myocardial infarction. In heart failure, by reducing afterload and preload through vasodilation and reduced fluid retention, it improves cardiac function and alleviates symptoms like breathlessness and fatigue.

The quality of the raw material API is paramount in pharmaceutical manufacturing. Impurities, even in small amounts, can affect the stability, efficacy, and safety of the final drug product. Therefore, sourcing Benazepril Hydrochloride raw material powder that meets stringent pharmacopoeial standards such as USP and BP, and is produced under GMP guidelines, is non-negotiable for drug manufacturers.

Ensuring batch-to-batch consistency, controlling particle size distribution, and providing comprehensive documentation, including Certificates of Analysis (CoA) and regulatory support, are key requirements for a reliable API supplier. A shelf life of typically 2 years is expected for the stable powder form when stored under appropriate conditions.

The global demand for high-quality APIs like Benazepril Hydrochloride remains strong, driven by the increasing prevalence of cardiovascular diseases worldwide. Pharmaceutical companies require partners in the supply chain who can not only provide material of impeccable quality but also ensure security of supply and competitive pricing.

For pharmaceutical manufacturers seeking a trusted source for this critical API, NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated supplier of high-purity Benazepril HCl raw material powder. With a focus on quality control and adherence to international pharmaceutical standards, NINGBO INNO PHARMCHEM CO.,LTD. ensures that its product meets the stringent requirements of the global market. Our commitment to excellence in manufacturing and supply chain management makes us a preferred partner for pharmaceutical companies worldwide.

If you are looking for a reliable Benazepril HCl manufacturer committed to quality and consistency, NINGBO INNO PHARMCHEM CO.,LTD. offers a robust supply solution. As a leading Benazepril Hydrochloride supplier, we understand the critical nature of pharmaceutical raw materials and provide comprehensive support to our clients. To inquire about the Benazepril HCl price or to learn more about our product specifications, please contact us directly. Navigating the process to buy Benazepril Hydrochloride powder should be straightforward and secure, and we strive to make it so for all our partners. For those needing to purchase Benazepril HCl raw material for their production needs, NINGBO INNO PHARMCHEM CO.,LTD. offers a reliable source with assured quality and competitive terms. Our team is ready to assist you with your requirements and provide detailed information regarding our product and services.