In the evolving landscape of global health, the escalating challenge of antimicrobial resistance (AMR) highlights the indispensable role of potent antibiotics. Among these, Colistin Sulfate (CAS 1264-72-8) stands as a critical last-resort agent, particularly against challenging Gram-negative bacterial infections. NINGBO INNO PHARMCHEM CO.,LTD. is proud to be a reliable manufacturer and supplier of high-ppurity Colistin Sulfate, providing essential solutions for pharmaceutical and veterinary applications worldwide.

Colistin Sulfate, also known as Polymyxin E, is a cationic, cyclic polypeptide antibiotic derived from the bacterium *Paenibacillus polymyxa subsp. colistinus*. It is typically a white powder, recognized for its exceptional purity and adherence to rigorous pharmaceutical standards such as GMP, USP, BP, EP, and ISO 9001. This commitment to quality ensures that our Colistin Sulfate meets the stringent requirements of a diverse range of applications.

The mechanism of action of Colistin Sulfate is highly effective, primarily targeting the outer membrane of Gram-negative bacteria. It achieves its bactericidal effect by interacting electrostatically with the negatively charged lipopolysaccharide (LPS) layer, specifically the lipid A component. This interaction displaces essential divalent cations like magnesium and calcium, leading to a profound disruption of the outer membrane's integrity. The compromised membrane becomes permeable, causing leakage of intracellular components and ultimately leading to bacterial cell lysis and death. Beyond its direct antibacterial properties, Colistin also exhibits valuable anti-endotoxin activity, neutralizing the lipid A portion of LPS which can trigger inflammatory responses during infection.

The versatility of Colistin Sulfate is evident in its wide array of applications. In veterinary medicine, it is extensively used for the treatment and prevention of enteritis in production animals such as pigs and poultry. It has also historically served as a growth promoter, contributing to animal health and productivity. In human medicine, Colistin Sulfate is invaluable for combating multidrug-resistant (MDR) Gram-negative bacterial infections, including those caused by *Pseudomonas aeruginosa*, *Klebsiella pneumoniae*, *Acinetobacter baumannii*, and *Escherichia coli*. Its use is often reserved for critically ill patients, those undergoing cancer chemotherapy, or organ transplant recipients, where other antibiotic options have become ineffective. While Colistin Sulfate is typically administered orally for digestive tract decontamination and topically for skin infections, its prodrug form, colistimethate sodium (CMS), is preferred for parenteral administration due to its lower systemic toxicity.

However, the increasing prevalence of antimicrobial resistance remains a significant global concern. The emergence of plasmid-mediated resistance genes, notably the *mcr* gene family (*mcr-1* to *mcr-10*), has led to a re-evaluation of Colistin as a "last-resort" antibiotic. This necessitates judicious use and robust antimicrobial stewardship programs to preserve its efficacy. Combining Colistin with other antibiotics, known as combination therapy, has shown promising synergistic activity against resistant strains, offering a potential pathway to overcome this evolving challenge.

As a dedicated Colistin Sulfate manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. understands the critical importance of reliable supply. We ensure a consistent production capacity of high-purity Colistin Sulfate, offering flexible packaging options such as 1kg bags and 25kg drums. For those looking to buy Colistin Sulfate, we provide competitive Colistin Sulfate prices and offer samples to facilitate quality verification. Our efficient logistics ensure a delivery lead time of approximately 5-10 days after payment confirmation. We invite you to purchase Colistin Sulfate from a trusted Colistin Sulfate supplier committed to quality and safety, contributing to effective solutions in both human and animal health.