FAPy-adenine, also known as 4,6-diamino-5-N-formamidopyrimidine, with CAS number 5122-36-1, stands as a molecule of increasing interest in biomedical research. As an oxidized DNA base, its presence and levels are crucial indicators in various biological processes, particularly those related to cellular damage and disease progression. Researchers globally are investigating its unique properties and its implications for understanding complex health conditions.

This compound presents as a solid with the molecular formula C5H7N5O and a molecular weight of 153.14. Its density typically ranges from 1.4 to 1.575 g/cm3. NINGBO INNO PHARMCHEM CO.,LTD. ensures a high purity level, generally exceeding 97% or 98%, making it suitable for sensitive research applications. FAPy-adenine is soluble in solvents such as DMSO, with sonication often recommended to achieve clear solutions for experimental use. Proper storage at low temperatures, specifically -20°C for powder and -80°C when in solution, is essential to maintain its integrity and stability over time, ensuring reliable results in laboratory settings.

The biological significance of FAPy-adenine primarily stems from its role as an oxidized DNA base. Studies have consistently shown that elevated levels of FAPy-adenine are observed in the brains of patients afflicted with Alzheimer's disease. This trend suggests a strong correlation between this oxidized nucleoside and neurodegenerative conditions, pointing towards increased nuclear DNA damage caused by oxygen-derived radicals. Consequently, FAPy-adenine is emerging as a significant biochemical marker for aging, tumor development, and various neurodegenerative disorders, including but not limited to Alzheimer's. Its detection provides valuable insights into the extent of oxidative stress within biological systems.

At a molecular level, FAPy-adenine demonstrates intriguing behavior. In the absence of an external field, it possesses the capability to form pairs with all four canonical nucleic acid bases. However, when an external field is introduced, its mispairing abilities become less significant, as the most stable dimers are preferentially formed with thymine. This selective pairing highlights its unique chemical reactivity and potential interactions within the complex environment of DNA. Understanding these fundamental interactions is vital for researchers aiming to develop new diagnostic tools or therapeutic strategies that target DNA damage pathways.

At NINGBO INNO PHARMCHEM CO.,LTD., we are committed to being a reliable manufacturer and supplier of high-quality FAPy-adenine (CAS 5122-36-1). Our long-standing expertise in chemical synthesis ensures that we provide products meeting stringent purity standards, critical for advanced scientific research. We understand the importance of consistency and reliability in chemical intermediates, especially for sensitive applications in biotechnology and medicine. Our production processes adhere to rigorous quality control protocols, guaranteeing the integrity and performance of every batch.

For researchers and institutions looking to purchase FAPy-adenine in various quantities, NINGBO INNO PHARMCHEM CO.,LTD. offers flexible packaging options, from grams to bulk amounts, tailored to meet diverse project needs. We strive to offer a competitive price without compromising on product excellence, making high-grade FAPy-adenine accessible for a wide range of studies. Whether you need a small quantity for initial experiments or a bulk supply for larger-scale research, our dedicated team is ready to assist with your inquiry. We provide professional support to facilitate a smooth buy process, ensuring that our customers receive the necessary chemical intermediates efficiently. We invite you to contact us for detailed product specifications, availability, and competitive pricing for your research needs.