6-Hydroxypurine, commonly known as Hypoxanthine (CAS 68-94-0), is a vital naturally occurring purine derivative. This indispensable compound plays a multifaceted role across numerous biological processes and has become an essential reagent in various scientific and industrial applications. Its chemical formula is C5H4N4O, and it possesses a molecular weight of 136.112 g/mol. Typically appearing as a white to off-white, odorless powder, Hypoxanthine exhibits a high melting point exceeding 300 °C, indicating its thermal stability. While practically insoluble in water, it demonstrates solubility in dilute acids and bases, such as 1 M NaOH, which is crucial for its application in diverse experimental settings.

Biologically, Hypoxanthine is a key player in the intricate network of purine metabolism. It is a fundamental intermediate in the biosynthesis of nucleic acids and energy pathways. Notably, it exists as a constituent of nucleic acids, particularly as the nucleoside inosine, found in the anticodon of transfer RNA (tRNA), where it facilitates wobble base pairing during protein synthesis. Furthermore, Hypoxanthine is a product of purine degradation, formed through the action of xanthine oxidoreductase on xanthine, and is subsequently converted to inosine monophosphate (IMP) via hypoxanthine-guanine phosphoribosyltransferase in nucleotide salvage pathways. Its presence is also linked to the spontaneous deamination of adenine, a process that can lead to errors in DNA transcription and replication, highlighting its significance in DNA integrity and repair mechanisms, where it is removed by base excision repair.

Beyond its direct involvement in genetic material, Hypoxanthine holds broader biological relevance. It is a necessary additive in the culture of various cells, bacteria, and parasites, including the malaria-causing parasite Plasmodium falciparum, which relies on Hypoxanthine for nucleic acid synthesis and energy metabolism. In a clinical context, elevated levels of Hypoxanthine in spinal fluid are observed in patients with Lesch-Nyhan syndrome, a severe metabolic disorder. Moreover, it serves as a valuable marker for energy perturbation under conditions of hypoxia or ischemia, demonstrating its utility in monitoring physiological stress. Research also indicates its ability to stimulate cell death and induce reactive oxygen species (ROS), contributing to posthypoxic reoxygenation cell injury. Interestingly, studies have even suggested the potential extraterrestrial formation of Hypoxanthine and related organic molecules, emphasizing its fundamental nature in the universe.

The diverse properties of Hypoxanthine make it invaluable across a wide spectrum of research and industrial applications. In pharmaceutical development, it is employed to induce hyperuricemia in animal models, aiding in the discovery and testing of novel hypouricemic agents. As a versatile biochemical, it is used in DNA studies to explore its destabilizing effect on DNA duplexes and to investigate interactions with DNA polymerases. Its role as a pharmaceutical intermediate further underscores its importance in the synthesis of various active pharmaceutical ingredients. Researchers consistently rely on high-purity Hypoxanthine for accurate and reproducible results in their complex experiments, ranging from cell biology and microbiology to drug discovery.

For laboratories and manufacturing facilities seeking this critical compound, securing a reliable supply of high-purity 6-Hydroxypurine is paramount. Leading chemical suppliers and manufacturers ensure that their Hypoxanthine meets stringent quality standards, often providing certificates of analysis to verify purity and specifications. When you aim to buy Hypoxanthine, consider the supplier's commitment to quality control and their ability to provide consistent batches. The price of Hypoxanthine can vary based on purity, quantity, and market dynamics, so it is advisable to request detailed quotations for your specific purchase needs. As a dedicated manufacturer and supplier of premium chemical compounds, we are committed to providing top-grade 6-Hydroxypurine, ensuring its suitability for your most demanding applications. We strive to offer competitive pricing and efficient service for every inquiry, facilitating a seamless procurement process for researchers and industrial clients worldwide.