Isopropylmagnesium Bromide: An Indispensable Reagent in Modern Synthesis

Isopropylmagnesium Bromide, often referred to as Isopropylbromomagnesium, with its Chemical Abstracts Service (CAS) number 920-39-8, stands as a cornerstone in the realm of advanced organic synthesis. This highly reactive Grignard reagent, characterized by its molecular formula C3H7BrMg and a molecular weight of 147.30 g/mol, is a colorless to light brown solution, typically supplied in solvents like tetrahydrofuran (THF) or 2-methyltetrahydrofuran (2-MeTHF) at varying concentrations, such as 1.0-2.0 M or 2.9 M.

The chemical prowess of Isopropylmagnesium Bromide lies in its exceptional reactivity. As a potent Grignard reagent, it is extensively utilized for nucleophilic additions and the crucial formation of carbon-carbon bonds. Its ability to efficiently react with various carbonyl compounds, including ketones, aldehydes, and esters, to yield tertiary alcohols makes it invaluable. Beyond these transformations, it also functions effectively as a strong base for deprotonation reactions, further expanding its synthetic utility. Due to its pyrophoric nature and extreme sensitivity to moisture and air, stringent handling protocols under an inert atmosphere, such as nitrogen or argon, are paramount to maintain its stability and reactivity.

The applications of Isopropylmagnesium Bromide span across a multitude of critical industries. In the pharmaceutical sector, it serves as a vital intermediate for synthesizing complex drug molecules, facilitating the creation of active pharmaceutical ingredients (APIs). Its precision in carbon-carbon bond formation is key to developing new therapeutic compounds. Similarly, the agrochemical industry leverages this reagent for the synthesis of advanced crop protection chemicals, including herbicides, insecticides, and fungicides, contributing to enhanced agricultural productivity and food safety. Furthermore, its role extends to fine chemical synthesis, enabling the production of specialized chemicals with high purity and specific functionalities demanded by various high-tech applications. In polymer chemistry, Isopropylmagnesium Bromide participates in polymerization reactions, influencing the properties and structures of novel polymeric materials.

Maintaining the integrity and performance of such a reactive compound requires meticulous attention to storage conditions. It is imperative to store Isopropylmagnesium Bromide under a controlled inert atmosphere at cool temperatures, typically between 2-8°C, in flame-proof containers to prevent degradation and ensure safety. This careful handling guarantees that the product retains its high reactivity and purity, which are essential for successful and reproducible synthetic outcomes.

For research institutions and industrial partners seeking a reliable supplier of high-quality Isopropylmagnesium Bromide, NINGBO INNO PHARMCHEM CO.,LTD. offers a consistent and robust supply chain. As a dedicated manufacturer of fine chemicals and pharmaceutical intermediates, we ensure that every batch of Isopropylmagnesium Bromide (CAS 920-39-8) meets rigorous quality standards, providing the purity and consistency required for demanding synthetic applications. To purchase this essential Grignard reagent or inquire about its price, interested parties are encouraged to reach out directly. Our commitment is to facilitate access to critical chemical building blocks, supporting innovation and production across diverse industries. We provide comprehensive technical support and competitive pricing to meet the specific needs of our global clientele.