In the complex landscape of pharmaceutical raw materials, certain compounds stand out for their critical role in life-saving treatments. Levofolinic Acid, with CAS number 68538-85-2, is one such indispensable ingredient, particularly in the field of oncology. As a high-purity powder, this raw material is foundational for formulations that have a significant impact on cancer patient outcomes.

Levofolinic acid is the biologically active l-isomer of folinic acid. Unlike folic acid, it does not require reduction by the enzyme dihydrofolate reductase to participate in essential metabolic reactions. This characteristic is paramount to its two primary functions in medicine. Firstly, it acts as a potent biochemical modulator, most famously used in combination with 5-fluorouracil (5-FU) for the treatment of advanced colorectal cancer. Levofolinic acid enhances the binding of 5-FU's active metabolite to the enzyme thymidylate synthase, thereby increasing its cytotoxic effects and making the chemotherapy more effective against cancer cells.

Secondly, Levofolinic acid serves as a crucial 'rescue' agent in high-dose methotrexate therapy. Methotrexate, a powerful folic acid antagonist, can be toxic to healthy cells. Levofolinic acid is administered to 'rescue' normal cells from these toxic effects by replenishing the body's pool of active folate, without diminishing the anti-cancer efficacy of the methotrexate. It is also used to treat megaloblastic anemia resulting from folic acid deficiency.
Given its direct involvement in critical care therapies, the quality of Levofolinic Acid powder is non-negotiable. Pharmaceutical manufacturers require a raw material that is not only high in purity, typically 99% or higher, but also consistent and reliable to ensure the safety and efficacy of the final drug product.

At NINGBO INNO PHARMCHEM CO.,LTD., we specialize in the production of these high-grade active pharmaceutical ingredients (APIs). As a dedicated manufacturer and supplier of Levofolinic Acid powder, we understand the stringent requirements of the pharmaceutical industry. Our commitment to quality ensures that our clients receive a product that meets the highest standards, such as those specified by the USP. For pharmaceutical companies looking to buy or source this essential API, it is vital to partner with a trusted provider. To inquire about the price or to make a purchase of our high-purity Levofolinic Acid powder, we encourage you to connect with our team. We are committed to supporting the advancement of oncological treatments through the reliable supply of superior quality raw materials.